Evidence map›Paper›PMID 33331995›Full record

ArticleInternational journal of legal medicine2021

Automated age estimation of young individuals based on 3D knee MRI using deep learning.

Markus Auf der Mauer, Eilin Jopp-van Well, Jochen Herrmann, Michael Groth, Michael M Morlock, Rainer Maas, Dennis Säring

Open access · hybridAbstract read
In one paragraph

Article in International journal of legal medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 1 pooled it
58.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 1 synthesis or guideline pooled it, 59 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Markus Auf der MauerMedical and Industrial Image Processing, University of Applied Sciences of Wedel, Feldstraße 143, 22880, Wedel, Germany. markusalexander.adm@gmail.com.ORCID http://orcid.org/0000-0002-5589-3681
Eilin Jopp-van WellDepartment of Legal Medicine, University Medical Center Hamburg-Eppendorf (UKE), Butenfeld 34, 22529, Hamburg, Germany.
Jochen HerrmannSection of Pediatric Radiology, Department of Diagnostic and Interventional Radiology and Nuclear Medicine, University Medical Center Hamburg-Eppendorf (UKE), Martinistr. 52, 20246, Hamburg, Germany.
Michael GrothSection of Pediatric Radiology, Department of Diagnostic and Interventional Radiology and Nuclear Medicine, University Medical Center Hamburg-Eppendorf (UKE), Martinistr. 52, 20246, Hamburg, Germany.
Michael M MorlockInstitute of Biomechanics M3, Hamburg University of Technology (TUHH), Denickestraße 15, 21073, Hamburg, Germany.
Rainer MaasRadiologie Raboisen 38, Raboisen 38, 20095, Hamburg, Germany.
Dennis SäringMedical and Industrial Image Processing, University of Applied Sciences of Wedel, Feldstraße 143, 22880, Wedel, Germany.
Universität Hamburg · DEUniversity of Applied Sciences Wedel · DE

Funding

Deutsche Forschungsgemeinschaft JO 1198/2-1Deutsche Forschungsgemeinschaft SA 2530/6-1
6 · The paper itself

Abstract

Age estimation is a crucial element of forensic medicine to assess the chronological age of living individuals without or lacking valid legal documentation. Methods used in practice are labor-intensive, subjective, and frequently comprise radiation exposure. Recently, also non-invasive methods using magnetic resonance imaging (MRI) have evaluated and confirmed a correlation between growth plate ossification in long bones and the chronological age of young subjects. However, automated and user-independent approaches are required to perform reliable assessments on large datasets. The aim of this study was to develop a fully automated and computer-based method for age estimation based on 3D knee MRIs using machine learning. The proposed solution is based on three parts: image-preprocessing, bone segmentation, and age estimation. A total of 185 coronal and 404 sagittal MR volumes from Caucasian male subjects in the age range of 13 and 21 years were available. The best result of the fivefold cross-validation was a mean absolute error of 0.67 ± 0.49 years in age regression and an accuracy of 90.9%, a sensitivity of 88.6%, and a specificity of 94.2% in classification (18-year age limit) using a combination of convolutional neural networks and tree-based machine learning algorithms. The potential of deep learning for age estimation is reflected in the results and can be further improved if it is trained on even larger and more diverse datasets.

Indexed as

Deep LearningImage Processing, Computer-AssistedMachine LearningMagnetic Resonance ImagingNeural Networks, ComputerAdolescentAge Determination by SkeletonAlgorithmsAutomationHumansImaging, Three-DimensionalKneeMaleYoung AdultAge estimationConvolutional neural networksKneeMachine learningMagnetic resonance imaging

Identifiers

PMID33331995
PMCPMC7870623
OpenAlexW3113307991

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.