Evidence map›Paper›PMID 33331926›Full record

ArticleBlood2020

Combinatorial treatment with menin and FLT3 inhibitors induces complete remission in AML models with activating FLT3 mutations.

Hongzhi Miao, EunGi Kim, Dong Chen, Trupta Purohit, Katarzyna Kempinska, James Ropa, Szymon Klossowski, Winifred Trotman, Gwenn Danet-Desnoyers, Tomasz Cierpicki and 1 more

Open access · bronzeAbstract readClinical Trial, Phase IMulticenter Study
In one paragraph

Article in Blood, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
2.7field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 38 citations in OpenAlex.

  1. Review
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  9. CharacterizingCancers · 2026
    Article
  10. Review
  11. [Allogeneic hematopoietic stem cell transplantation for pediatric acute leukemia harboring theZhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2025
    Article
  12. Menin in Cancer.Genes · 2024
    Review
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
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  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Hongzhi MiaoDepartment of Pathology, University of Michigan, Ann Arbor, MI.
EunGi KimDepartment of Pathology, University of Michigan, Ann Arbor, MI.
Dong ChenDepartment of Pathology, University of Michigan, Ann Arbor, MI.
Trupta PurohitDepartment of Pathology, University of Michigan, Ann Arbor, MI.
Katarzyna KempinskaDepartment of Pathology, University of Michigan, Ann Arbor, MI.
James RopaDepartment of Microbiology and Immunology, School of Medicine, Indiana University, Indianapolis, IN; and.
Szymon KlossowskiDepartment of Pathology, University of Michigan, Ann Arbor, MI.
Winifred TrotmanDivision of Hematology-Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.
Gwenn Danet-DesnoyersDivision of Hematology-Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.
Tomasz CierpickiDepartment of Pathology, University of Michigan, Ann Arbor, MI.
Jolanta GrembeckaDepartment of Pathology, University of Michigan, Ann Arbor, MI.
University of Michigan · USUniversity of Pennsylvania · USIndiana University Indianapolis · US

Funding

XenograftP30CA046592 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Alexey I Nesvizhskii · 1988 to 2026
$178.2M
REGULATION OF HEMATOPOIETIC CELL PRODUCTIONT32DK007519 · NIDDK · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI KAPLAN, MARK H · 1986 to 2020
$7.1M
Development of novel anti-leukemia agents targeting the menin-MLL interactionR01CA160467 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI GREMBECKA, JOLANTA · 2011 to 2021
$3.4M
Targeting NSD1 in leukemiaR01CA226759 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CIERPICKI, TOMASZ · 2019 to 2023
$2.3M
Development of small molecules targeting Ring1B-Bmi1 E3 ligase in leukemiaR01CA207272 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CIERPICKI, TOMASZ · 2016 to 2020
$2.0M
Targeting protein-protein interactions of Bmi1 oncoproteinR01CA201204 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI GREMBECKA, JOLANTA · 2016 to 2018
$959k
NCI NIH HHS P30 CA046592NCI NIH HHS R01 CA160467NCI NIH HHS R01 CA201204NCI NIH HHS R01 CA207272NCI NIH HHS R01 CA226759NIDDK NIH HHS T32 DK007519
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

fms-Like Tyrosine Kinase 3Leukemia, Myeloid, AcuteModels, BiologicalMutationProto-Oncogene ProteinsAntineoplastic Combined Chemotherapy ProtocolsFemaleHumansMaleProtein Kinase InhibitorsFLT3 protein, humanfms-Like Tyrosine Kinase 3MEN1 protein, humanProtein Kinase InhibitorsProto-Oncogene Proteins

Identifiers

PMID33331926
PMCPMC7751359
OpenAlexW3092458827

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.