ArticleeLife2020
Topographic gradients of intrinsic dynamics across neocortex.
Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 109 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
109 citing papers in PubMed.
- Spatiotemporal mapping of brain organisation following the administration of 2C-B and psilocybin.Molecular psychiatry · 2026Trial
- Methylphenidate reorganizes cortical hierarchy through dopaminergic modulation.Nature communications · 2025Trial
- Comprehensive profiling of brain dynamics during anesthesia across phylogeny.Nature neuroscience · 2026Article
- Intrinsic timescale develops hierarchically from sensorimotor to association cortex in youth and stabilizes in adulthood.PLoS biology · 2026Article
- Anatomical white matter tracts span the cortical hierarchy to support cognitive diversity.Nature human behaviour · 2026Article
- Spatially structured heterogeneity shapes large-scale cortical dynamics in a model of the human cortex.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Neural timescales from a computational perspective.Nature neuroscience · 2026Review
- Neuromorphic hierarchical modular reservoirs.Nature communications · 2026Article
- Categorization is 'baked' into the brain.Nature reviews. Neuroscience · 2026Review
- Association-sensory spatiotemporal hierarchy and functional gradient-regularised recurrent neural network with implications for schizophrenia.NPJ systems biology and applications · 2026Article
- Spinal cord structural and functional architecture and its shared organization with the brain across the adult lifespan.Nature communications · 2026Article
- Brain network dynamics determine tau presence while regional vulnerability governs tau load in Alzheimer's disease.Research square · 2026Article
- Geometry of neural dynamics along the cortical attractor landscape reflects changes in attention.Nature communications · 2026Article
- Synapse types are spatially associated with regional hemodynamics in the mouse brain.PLoS biology · 2026Article
- Spontaneous brain regional dynamics contribute to generalizable brain-behaviour associations.Nature human behaviour · 2026Article
- The biological role of local and global fMRI BOLD signal variability in multiscale human brain organization.Nature communications · 2026Article
- Temporal and Spatial Scales of Human Resting-State Cortical Activity across the Lifespan.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Five energy metabolism pathways show distinct regional distributions and lifespan trajectories in the human brain.PLoS biology · 2026Article
- New directions for complex systems in contemporary neuroscience: a morphodynamic and emergent function approach.Frontiers in computational neuroscience · 2026Review
- Network hierarchy in Alzheimer's and Lewy body spectrum disorders: functional gradients, cognitive phenotypes, and translational gaps.Frontiers in aging neuroscience · 2026Review
49 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
The intrinsic dynamics of neuronal populations are shaped by both microscale attributes and macroscale connectome architecture. Here we comprehensively characterize the rich temporal patterns of neural activity throughout the human brain. Applying massive temporal feature extraction to regional haemodynamic activity, we systematically estimate over 6000 statistical properties of individual brain regions' time-series across the neocortex. We identify two robust spatial gradients of intrinsic dynamics, one spanning a ventromedial-dorsolateral axis and dominated by measures of signal autocorrelation, and the other spanning a unimodal-transmodal axis and dominated by measures of dynamic range. These gradients reflect spatial patterns of gene expression, intracortical myelin and cortical thickness, as well as structural and functional network embedding. Importantly, these gradients are correlated with patterns of meta-analytic functional activation, differentiating cognitive
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.