Evidence map›Paper›PMID 33331815›Full record

ArticleThe Journal of general virology2021

The origins of G12P[6] rotavirus strains detected in Lebanon.

Lina Reslan, Nischay Mishra, Marc Finianos, Kimberley Zakka, Amanda Azakir, Cheng Guo, Riddhi Thakka, Ghassan Dbaibo, W Ian Lipkin, Hassan Zaraket

Open access · greenAbstract readMulticenter Study
In one paragraph

Article in The Journal of general virology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.1field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Lina ReslanCenter for Infectious Diseases Research, American University of Beirut, Faculty of Medicine, Beirut, Lebanon.
Nischay MishraCenter for Infection and the Immunity, Mailman School of Public Health, Columbia University, NY 10032, New York.
Marc FinianosCenter for Infectious Diseases Research, American University of Beirut, Faculty of Medicine, Beirut, Lebanon.
Kimberley ZakkaCenter for Infectious Diseases Research, American University of Beirut, Faculty of Medicine, Beirut, Lebanon.
Amanda AzakirDepartment of Experimental Pathology, Immunology and Microbiology, Faculty of Medicine, Beirut, Lebanon.
Cheng GuoCenter for Infection and the Immunity, Mailman School of Public Health, Columbia University, NY 10032, New York.
Riddhi ThakkaCenter for Infection and the Immunity, Mailman School of Public Health, Columbia University, NY 10032, New York.
Ghassan DbaiboDepartment of Pediatrics and Adolescent Medicine, American University of Beirut, Faculty of Medicine, Beirut, Lebanon.
W Ian LipkinCenter for Infection and the Immunity, Mailman School of Public Health, Columbia University, NY 10032, New York.
Hassan ZaraketDepartment of Experimental Pathology, Immunology and Microbiology, Faculty of Medicine, Beirut, Lebanon.
American University of Beirut · LBColumbia University · US

Funding

Translational CoreU19AI109761 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI BARIC, RALPH S · 2014 to 2018
$32.6M
NIAID NIH HHS U19 AI109761
6 · The paper itself

Abstract

The G12 rotaviruses are an increasingly important cause of severe diarrhoea in infants and young children worldwide. Seven human G12P[6] rotavirus strains were detected in stool samples from children hospitalized with gastroenteritis in Lebanon during a 2011-2013 surveillance study. Complete genomes of these strains were sequenced using VirCapSeq-VERT, a capture-based high-throughput viral-sequencing method, and further characterized based on phylogenetic analyses with global RVA and vaccine strains. Based on the complete genomic analysis, all Lebanese G12 strains were found to have Wa-like genetic backbone G12-P[6]-I1-R1-C1-M1-A1-N1-T1-E1-H1. Phylogenetically, these strains fell into two clusters where one of them might have emerged from Southeast Asian strains and the second one seems to have a mixed backbone between North American and Southeast Asian strains. Further analysis of these strains revealed high antigenic variability compared to available vaccine strains. To our knowledge, this is the first report on the complete genome-based characterization of G12P[6] emerging in Lebanon. Additional studies will provide important insights into the evolutionary dynamics of G12 rotaviruses spreading in Asia.

Indexed as

Genome, ViralAntigens, ViralAsia, SoutheasternCapsid ProteinsChild, PreschoolEpitopesEvolution, MolecularFemaleGastroenteritisGlycosylationHumansInfantInfant, NewbornLebanonMaleNorth AmericaAntigens, ViralCapsid ProteinsEpitopesRIX4414 vaccineRotaTeqRotavirus VaccinesVaccines, AttenuatedViral ProteinsVP4 protein, RotavirusVP7 protein, RotavirusG12P[6]GenomeHuman Rotavirus ALebanonVirCapSeq-VERT

Identifiers

PMID33331815
PMCPMC8515856
OpenAlexW3110650233

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.