Evidence map›Paper›PMID 33331774›Full record

ArticleMolecular pharmaceutics2021

Potential Roles of the Glass Transition Temperature of PLGA Microparticles in Drug Release Kinetics.

Kinam Park, Andrew Otte, Farrokh Sharifi, John Garner, Sarah Skidmore, Haesun Park, Young Kuk Jhon, Bin Qin, Yan Wang

Open access · greenAbstract read
In one paragraph

Article in Molecular pharmaceutics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
3.5field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 88 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. How PLGA Microspheres are Emerging as a Key Drug Delivery System.International journal of nanomedicine · 2026
    Review
  5. Article
  6. Release mechanisms of PLGA-based drug delivery systems: A review.International journal of pharmaceutics: X · 2025
    Article
  7. Long-Acting injectable buprenorphine PLGA microparticle formulation.International journal of pharmaceutics · 2025
    Article
  8. Article
  9. PLGA-based long-acting injectable (LAI) formulations.Journal of controlled release : official journal of the Controlled Release Society · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Kinam ParkWeldon School of Biomedical Engineering, Purdue University, West Lafayette, Indiana 47907, United States.ORCID 0000-0001-8202-6084
Andrew OtteWeldon School of Biomedical Engineering, Purdue University, West Lafayette, Indiana 47907, United States.
Farrokh SharifiWeldon School of Biomedical Engineering, Purdue University, West Lafayette, Indiana 47907, United States.
John GarnerAkina, Inc., West Lafayette, Indiana 47906, United States.
Sarah SkidmoreAkina, Inc., West Lafayette, Indiana 47906, United States.
Haesun ParkAkina, Inc., West Lafayette, Indiana 47906, United States.
Young Kuk JhonOffice of Pharmaceutical Quality, Food and Drug Administration, Center for Drug Evaluation and Research, Silver Spring, Maryland 20993, United States.
Bin QinOffice of Generic Drugs, Food and Drug Administration, Center for Drug Evaluation and Research, Silver Spring, Maryland 20993, United States.
Yan WangOffice of Generic Drugs, Food and Drug Administration, Center for Drug Evaluation and Research, Silver Spring, Maryland 20993, United States.
Akina (United States) · USCenter for Drug Evaluation and Research · USPurdue University West Lafayette · US

Funding

Injectable naltrexone 2-month depot formulationsUH3DA048774 · NIDA · PURDUE UNIVERSITY · PI PARK, KINAM · 2022 to 2024
$4.9M
Injectable naltrexone 2-month depot formulationsUG3DA048774 · NIDA · PURDUE UNIVERSITY · PI PARK, KINAM · 2019 to 2020
$2.9M
NIDA NIH HHS UG3 DA048774NIDA NIH HHS UH3 DA048774
6 · The paper itself

Abstract

Poly(lactic-

Indexed as

Drug CarriersDrug Delivery SystemsDrug LiberationGlassKineticsMicroplasticsNanoparticlesParticle SizePolylactic Acid-Polyglycolic Acid CopolymerTransition TemperatureDrug CarriersMicroplasticsPolylactic Acid-Polyglycolic Acid Copolymerdrug release kineticsglass transition temperaturemicroparticlesnanoparticlesPLGAterminal sterilization

Identifiers

PMID33331774
PMCPMC9431771
OpenAlexW3115159199

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.