ArticleLab on a chip2021
Single-cell microfluidic impedance cytometry: from raw signals to cell phenotypes using data analytics.
Article in Lab on a chip, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
60 citing papers in PubMed.
- Isolating viable bacteria from positive blood cultures: impedance cytometry analysis.Biomedical microdevices · 2026Article
- Code-multiplexed multi-frequency impedance cytometry with a unified deep-unfolding network.Microsystems & nanoengineering · 2026Article
- Position-Independent Particle Sizing in High-Precision Impedance Cytometry via Full-Waveform Feature Calibration.Electrophoresis · 2026Article
- Event-Preserving Neural Network Denoising for Impedance Flow Cytometry.Nanomaterials (Basel, Switzerland) · 2026Article
- Real-Time Biophysical Phenotyping and Sorting of Transiting Cells Along a Constriction Microchannel.Micromachines · 2026Article
- IntravChip: a vascularized and perfused microfluidic model of the primary tumor microenvironment to collect intravasated tumor cells.Biofabrication · 2026Article
- Structural, Compositional, and Dielectric State Profiling in Label-Free Single-Cell Monitoring.Small methods · 2026Review
- Cellular level lipidomics of two-dimensional cultures of adherent gut epithelial cell lines confirms a metabolic switch.The Analyst · 2026Article
- IntravChip: a vascularized and perfused microfluidic model of the primary tumor microenvironment to collect intravasated tumor cells.bioRxiv : the preprint server for biology · 2026Article
- Label-free, machine-learning assisted impedance assessment of basophil activation.Sensors and actuators. B, Chemical · 2026Article
- A Derivative-Based Framework for Real-Time Signal Processing and Event Detection in Impedance Flow Cytometry.Sensors (Basel, Switzerland) · 2025Article
- Automated smartphone based cell analysis platform.Npj imaging · 2025Article
- Investigating the effects of plasma-activated water on E. coli with the novel application of single-cell impedance flow cytometry.Scientific reports · 2025Article
- Evaluating inkjet dispenser/liquid vortex capture-mass spectrometry for single-cell metabolomics in Hep G2 steatosis caused by tamoxifen.Analytical and bioanalytical chemistry · 2025Article
- On-Chip Integration of Impedance Cytometry for Inline Optimization of Dielectrophoretic Separations on Multiple Cellular Biophysical Metrics.ACS sensors · 2025Article
- Droplet Generation and Manipulation in Microfluidics: A Comprehensive Overview of Passive and Active Strategies.Biosensors · 2025Review
- Recent advances in bio-microsystem integration and Lab-on-PCB technology.Microsystems & nanoengineering · 2025Review
- Label-Free and Rapid Microfluidic Design Rules for Circulating Tumor Cell Enrichment and Isolation: A Review and Simulation Analysis.ACS omega · 2025Review
- Neural Network-Enabled Multiparametric Impedance Signal Templating for High throughput Single-Cell Deformability Cytometry Under Viscoelastic Extensional Flows.Small (Weinheim an der Bergstrasse, Germany) · 2025Article
- Microfluidic impedance flow cytometer leveraging virtual constriction microchannel and its application in leukocyte differential.Microsystems & nanoengineering · 2024Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
The biophysical analysis of single-cells by microfluidic impedance cytometry is emerging as a label-free and high-throughput means to stratify the heterogeneity of cellular systems based on their electrophysiology. Emerging applications range from fundamental life-science and drug assessment research to point-of-care diagnostics and precision medicine. Recently, novel chip designs and data analytic strategies are laying the foundation for multiparametric cell characterization and subpopulation distinction, which are essential to understand biological function, follow disease progression and monitor cell behaviour in microsystems. In this tutorial review, we present a comparative survey of the approaches to elucidate cellular and subcellular features from impedance cytometry data, covering the related subjects of device design, data analytics (i.e., signal processing, dielectric modelling, population clustering), and phenotyping applications. We give special emphasis to the exciting recent developments of the technique (timeframe 2017-2020) and provide our perspective on future challenges and directions. Its synergistic application with microfluidic separation, sensor science and machine learning can form an essential toolkit for label-free quantification and isolation of subpopulations to stratify heterogeneous biosystems.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.