Evidence map›Paper›PMID 33331040›Full record

Trial reportJournal of periodontology2021

Evaluating efficacy of a novel dentifrice in reducing probing depths in Stage I and II periodontitis maintenance patients: A randomized, double-blind, positive controlled clinical trial.

Maninder Kaur, Nicolaas C Geurs, Charles M Cobb, Joan Otomo-Corgel, Thair Takesh, June H Lee, Tracie M Lam, Kairong Lin, Audrey Nguyen, Brian L Nguyen and 1 more

Open access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of periodontology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 11 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Maninder KaurSchool of Dentistry, Department of Periodontology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Nicolaas C GeursSchool of Dentistry, Department of Periodontology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Charles M CobbDepartment of Periodontics, University of Missouri-Kansas City, Kansas City, Missouri, USA.
Joan Otomo-CorgelSchool of Dentistry, Department of Periodontology, University of California at Los Angles, Los Angeles, California, USA.
Thair TakeshBeckman Laser Institute and Medical Clinic, Department of Dentistry, University of California at Irvine, Irvine, California, USA.
June H LeeBeckman Laser Institute and Medical Clinic, Department of Dentistry, University of California at Irvine, Irvine, California, USA.
Tracie M LamBeckman Laser Institute and Medical Clinic, Department of Dentistry, University of California at Irvine, Irvine, California, USA.
Kairong LinBeckman Laser Institute and Medical Clinic, Department of Dentistry, University of California at Irvine, Irvine, California, USA.
Audrey NguyenBeckman Laser Institute and Medical Clinic, Department of Dentistry, University of California at Irvine, Irvine, California, USA.
Brian L NguyenBeckman Laser Institute and Medical Clinic, Department of Dentistry, University of California at Irvine, Irvine, California, USA.
Petra Wilder-SmithBeckman Laser Institute and Medical Clinic, Department of Dentistry, University of California at Irvine, Irvine, California, USA.
Beckman Laser Institute and Medical Clinic · USUniversity of Alabama at Birmingham · USUniversity of California, Los Angeles · USUniversity of Missouri–Kansas City · US

Funding

Univ.of Calif., Irvine Cancer Center Support GrantP30CA062203 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI Christine Hui · 1994 to 2026
$57.9M
Virtual Photonocs TechnologiesP41EB015890 · NIBIB · UNIVERSITY OF CALIFORNIA-IRVINE · PI DURKIN, ANTHONY · 2012 to 2017
$7.0M
Low-cost Mobile Oral Cancer Screening for Low Resource SettingUH2EB022623 · NIBIB · UNIVERSITY OF ARIZONA · PI LIANG, RONGGUANG · 2016 to 2017
$996k
NCI NIH HHS P30 CA062203NIBIB NIH HHS P41 EB015890NIBIB NIH HHS UH2 EB022623
6 · The paper itself

Abstract

backgroundCompliance to periodontal maintenance therapy (PMT) is essential for long-term periodontal health. Between PMT visits, patients must maintain good oral hygiene. A dentifrice with demonstrable clinical benefits for use between PMT visits would be highly desirable. The aim of this clinical study was to investigate the effect of a novel dental gel on probing depths (PD) and inflammation when used as a home care dentifrice in Stage I and II periodontitis patients.

methodsThis double-blind clinical study randomized 65 subjects with Stage I and II periodontitis to the novel dental gel containing 2.6% EDTA, and a commercially available anti-gingivitis dentifrice with 0.454% stannous fluoride. Primary endpoint was PD at 6 months for those sites with baseline PD ≥ 4 mm and secondary endpoints included whole mouth mean scores of modified gingival index (MGI), modified sulcus bleeding index (mSBI) and plaque index (PI). No SRP was performed at baseline.

resultsSubjects using the novel dentifrice showed significant PD reductions of 1.18 mm (from 4.27 mm at baseline to 3.09 mm at 6 months) compared to 0.93 mm (from 4.23 mm at baseline to 3.30 mm at 6 months) shown for those using the positive control dentifrice. Difference between treatments at 6 months was 0.21 mm with P-value = 0.0126. Significant improvements in MGI (P = 0.0000), mSBI (P = 0.0000), and PI (P = 0.0102) were also observed in 6 months.

conclusionThe novel dentifrice showed significant reductions in PD and gingival inflammation over 6 months solely as a home care dentifrice without baseline SRP in Stage I and II periodontitis maintenance patients.

Indexed as

DentifricesGingivitisPeriodontitisDental Plaque IndexDouble-Blind MethodHumansTin FluoridesDentifricesTin Fluoridesanti-inflammatory agentsoral hygieneperiodontitisplaque controltoothbrushing

Identifiers

PMID33331040
PMCPMC9984250
OpenAlexW3111479591

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.