Evidence map›Paper›PMID 33330867›Full record

ArticlebioRxiv : the preprint server for biology2020

Persistent Cellular Immunity to SARS-CoV-2 Infection.

Gaëlle Breton, Pilar Mendoza, Thomas Hagglof, Thiago Y Oliveira, Dennis Schaefer-Babajew, Christian Gaebler, Martina Turroja, Arlene Hurley, Marina Caskey, Michel C Nussenzweig

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 30 citations in OpenAlex.

  1. B cell persistence and evolution to SARS-CoV-2.Nature reviews. Immunology · 2021
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Gaëlle BretonLaboratory of Molecular Immunology, The Rockefeller University, New York, NY 10065, USA.
Pilar MendozaLaboratory of Molecular Immunology, The Rockefeller University, New York, NY 10065, USA.
Thomas HagglofLaboratory of Molecular Immunology, The Rockefeller University, New York, NY 10065, USA.
Thiago Y OliveiraLaboratory of Molecular Immunology, The Rockefeller University, New York, NY 10065, USA.
Dennis Schaefer-BabajewLaboratory of Molecular Immunology, The Rockefeller University, New York, NY 10065, USA.
Christian GaeblerLaboratory of Molecular Immunology, The Rockefeller University, New York, NY 10065, USA.
Martina TurrojaLaboratory of Molecular Immunology, The Rockefeller University, New York, NY 10065, USA.
Arlene HurleyHospital Program Direction, The Rockefeller University, New York, NY 10065, USA.
Marina CaskeyLaboratory of Molecular Immunology, The Rockefeller University, New York, NY 10065, USA.
Michel C NussenzweigLaboratory of Molecular Immunology, The Rockefeller University, New York, NY 10065, USA.
Rockefeller University · USHoward Hughes Medical Institute · USRockefeller University Hospital · US

Funding

Understanding B cell memory in response to diverse virus infectionsU19AI111825 · NIAID · ROCKEFELLER UNIVERSITY · PI RAVETCH, JEFFREY VICTOR · 2014 to 2023
$26.0M
NIAID NIH HHS U19 AI111825
6 · The paper itself

Abstract

SARS-CoV-2 is responsible for an ongoing pandemic that affected millions of individuals around the globe. To gain further understanding of the immune response in recovered individuals we measured T cell responses in paired samples obtained an average of 1.3 and 6.1 months after infection from 41 individuals. The data indicate that recovered individuals show persistent polyfunctional SARS-CoV-2 antigen specific memory that could contribute to rapid recall responses. In addition, recovered individuals show enduring immune alterations in relative numbers of CD4 SUMMARY: We show that SARS-CoV-2 infection elicits broadly reactive and highly functional memory T cell responses that persist 6 months after infection. In addition, recovered individuals show enduring immune alterations in CD4

Identifiers

PMID33330867
PMCPMC7743071
OpenAlexW3113266993

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.