Evidence map›Paper›PMID 33330731›Full record

ArticleOrthopaedic journal of sports medicine2020

The Influence of Obesity and Meniscal Coverage on In Vivo Tibial Cartilage Thickness and Strain.

Amber T Collins, Micaela Kulvaranon, Charles E Spritzer, Amy L McNulty, Louis E DeFrate

Open access · goldAbstract read
In one paragraph

Article in Orthopaedic journal of sports medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.2field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 18 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Amber T CollinsDepartment of Orthopaedic Surgery, Duke University School of Medicine, Durham, North Carolina, USA.
Micaela KulvaranonDepartment of Orthopaedic Surgery, Duke University School of Medicine, Durham, North Carolina, USA.
Charles E SpritzerDepartment of Radiology, Duke University School of Medicine, Durham, North Carolina, USA.
Amy L McNultyDepartment of Orthopaedic Surgery, Duke University School of Medicine, Durham, North Carolina, USA.
Louis E DeFrateDepartment of Orthopaedic Surgery, Duke University School of Medicine, Durham, North Carolina, USA.
Duke University · US

Funding

In Vivo Knee Motion and ACL Biomechanics During Dynamic ActivitiesR01AR065527 · NIAMS · DUKE UNIVERSITY · PI DEFRATE, LOUIS E. · 2014 to 2024
$4.8M
Mechanical Biomarkers of Chronic Low Back PainR01AR075399 · NIAMS · DUKE UNIVERSITY · PI Louis E. DeFrate, Adam Goode · 2019 to 2026
$3.7M
Weight loss, in vivo cartilage mechanics, and joint healthR01AR074800 · NIAMS · DUKE UNIVERSITY · PI DEFRATE, LOUIS E. · 2019 to 2023
$1.8M
NIAMS NIH HHS R01 AR065527NIAMS NIH HHS R01 AR074800NIAMS NIH HHS R01 AR075399
6 · The paper itself

Abstract

backgroundObesity, which potentially increases loading at the knee, is a common and modifiable risk factor for the development of knee osteoarthritis. The menisci play an important role in distributing joint loads to the underlying cartilage. However, the influence of obesity on the role of the menisci in cartilage load distribution in vivo is currently unknown. PURPOSE: To measure tibial cartilage thickness and compressive strain in response to walking in areas covered and uncovered by the menisci in participants with normal body mass index (BMI) and participants with high BMI. STUDY

designControlled laboratory study.

methodsMagnetic resonance (MR) images of the right knees of participants with normal BMI (<25 kg/m

resultsBefore exercise, medial and lateral uncovered cartilage of the tibial plateau was significantly thicker than covered cartilage in both BMI groups. In the uncovered region of the lateral tibial plateau, participants with high BMI had thinner preexercise cartilage than those with a normal BMI. Cartilage compressive strain was significantly greater in medial and lateral cartilage in participants with high BMI compared with those with normal BMI in both the regions covered and those uncovered by the menisci.

conclusionParticipants with high BMI experienced greater cartilage strain in response to walking than participants with normal BMI in both covered and uncovered regions of cartilage, which may indicate that the load-distributing function of the meniscus is not sufficient to moderate the effects of obesity. CLINICAL RELEVANCE: These findings demonstrate the critical effect of obesity on cartilage function and thickness in regions covered and uncovered by the menisci.

Indexed as

articular cartilageBMIimagingkneeMRI

Identifiers

PMID33330731
PMCPMC7720327
OpenAlexW3109046649

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.