ArticleFrontiers in veterinary science2020
Early Life Inoculation With Adult-Derived Microbiota Accelerates Maturation of Intestinal Microbiota and Enhances NK Cell Activation in Broiler Chickens.
Article in Frontiers in veterinary science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 38 citations in OpenAlex.
- Machine learning identifies key microbial signatures for Salmonella enteritidis colonization and persistence in broiler ceca.Poultry science · 2026Article
- Effects of In Ovo Injection of Mannan-Oligosaccharides on Early Growth Performance, Intestinal Morphology, and Cecal Microbiota in Broilers.Animals : an open access journal from MDPI · 2026Article
- Chick neonatal environment: the presence of a hen, not hatching system, promotes cecal microbiota development and induces limited long-term effects on immunity and redox balance.Poultry science · 2026Article
- Liver-muscle metabolic crosstalk: xanthosine as a key effector of broiler myogenesis.Journal of animal science and biotechnology · 2026Article
- Coccidiosis prevention strategies shape the microbiome, resistome and mobilome composition in the broiler gut.Animal microbiome · 2026Article
- Conserved functional features of natural killer cell subsets in chicken, human, and murine immune systems.iScience · 2025Article
- Rearing system and immune status influence the small intestinal microbiota of IPB-D3 chickens: A full-length 16S rRNA metagenomic approach.Veterinary world · 2025Article
- Recent advances in the application of microbiota transplantation in chickens.Journal of animal science and biotechnology · 2025Review
- Comparative Analysis of the Gut Microbiota of Thai Indigenous Chicken Fed House Crickets.Animals : an open access journal from MDPI · 2025Article
- Synthetic microbial community improves chicken intestinal homeostasis and provokes anti-Salmonella immunity mediated by segmented filamentous bacteria.The ISME journal · 2025Article
- Infectious bronchitis virus vaccination, but not the presence of XCR1, is correlated with large differences in chicken caecal microbiota.Microbial genomics · 2024Article
- Investigating the cecal microbiota of broilers raised in extensive and intensive production systems.Microbiology spectrum · 2023Article
- Colonization of the Gastrointestinal Tract of Chicks with Different Bacterial Microbiota Profiles.Animals : an open access journal from MDPI · 2023Article
- Cecal Microbiota Development and Physiological Responses of Broilers Following Early Life Microbial Inoculation Using Different Delivery Methods and Microbial Sources.Applied and environmental microbiology · 2023Article
- The Development of Gut Microbiota and Its Changes FollowingVaccines · 2023Review
- Diet Composition and Using Probiotics or Symbiotics Can Modify the Urinary and Faecal Nitrogen Ratio of Broiler Chicken's Excreta and Also the Dynamics of In Vitro Ammonia Emission.Animals : an open access journal from MDPI · 2023Article
- Lead induced structural and functional damage and microbiota dysbiosis in the intestine of crucian carp (Frontiers in microbiology · 2023Article
- Preventing bacterial disease in poultry in the post-antibiotic era: a case for innate immunity modulation as an alternative to antibiotic use.Frontiers in immunology · 2023Review
- Delayed access to feed early post-hatch affects the development and maturation of gastrointestinal tract microbiota in broiler chickens.BMC microbiology · 2022Article
- Chicken-derived RSPO1 and WNT3 contribute to maintaining longevity of chicken intestinal organoid cultures.Scientific reports · 2022Article
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Studies in mammals, including chickens, have shown that the development of the immune system is affected by interactions with intestinal microbiota. Early life microbial colonization may affect the development of innate and adaptive immunity and may contribute to lasting effects on health and resilience of broiler chickens. We inoculated broiler chickens with adult-derived-microbiota (AM) to investigate their effects on intestinal microbiota composition and natural killer (NK) cells, amongst other immune cells. We hypothesized that AM inoculation directly upon hatch (day 0) would induce an alteration in microbiota composition shortly after hatch, and subsequently affect (subsets of) intestinal NK cells and their activation. Microbiota composition of caecal and ileal content of chickens of 1, 3, 7, 14, 21, and 35 days of age was assessed by sequencing of 16S ribosomal RNA gene amplicons. In parallel, subsets and activation of intestinal NK cells were analyzed by flow cytometry. In caecal content of 1- and 3-day-old AM chickens, a higher alpha-diversity (Faith's phylogenetic diversity) was observed compared to control chickens, whereas ileal microbiota were unaffected. Regarding beta-diversity, caecal microbiota profiles could be clustered into three distinct community types. Cluster A represented caecal microbiota of 1-day-old AM chickens and 1- and 3-day-old control chickens. Cluster B included microbiota of seven of eight 3- and 7-day-old AM and 7-day-old control chickens, and cluster C comprised microbiota of all chickens of 14-days and older, independent of inoculation. In 3-day-old AM chickens an increase in the percentages of intestinal IL-2Rα
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.