Evidence map›Paper›PMID 33330641›Full record

ArticleFrontiers in cardiovascular medicine2020

Oxidized Low-Density Lipoprotein Induces WNT5A Signaling Activation in THP-1 Derived Macrophages and a Human Aortic Vascular Smooth Muscle Cell Line.

Ian Ackers, Candice Szymanski, Mitchell J Silver, Ramiro Malgor

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cardiovascular medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 17 citations in OpenAlex.

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  9. Scavenger receptor-targeted plaque delivery of microRNA-coated nanoparticles for alleviating atherosclerosis.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Ian AckersOsteopathic Heritage Foundation, Translational Biomedical Sciences Program, Ohio University, Athens, OH, United States.
Candice SzymanskiDepartment of Biomedical Sciences, Ohio University, Athens, OH, United States.
Mitchell J SilverMidwest Cardiology Research Foundation, Columbus, OH, United States.
Ramiro MalgorDepartment of Biomedical Sciences, Ohio University, Athens, OH, United States.
Ohio University · USMidwest Cardiovascular Research Foundation · US

Funding

Role of Wnt5a signaling in atherosclerosis, a potential therapeutic targetR15HL133885 · NHLBI · OHIO UNIVERSITY ATHENS · PI MALGOR, RAMIRO · 2017 to 2017
$453k
NHLBI NIH HHS R15 HL133885
6 · The paper itself

Abstract

The pathogenesis of atherosclerosis is complex, evolves, and involves many cell types. Macrophages and vascular smooth muscle cells (VSMCs) are critically involved in atherosclerosis development and progression. Several studies have shown that WNT5A protein is abundantly expressed in human atherosclerotic lesions; however, the mechanism and role of WNT signaling pathway activation is not clearly known. Using THP-1 derived macrophages, and human aortic VSMC cells, we evaluated

Indexed as

foam cellsmacrophagesvascular biologyvascular smooth muscle cellsWnt signaling

Identifiers

PMID33330641
PMCPMC7710548
OpenAlexW3104208330

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.