Evidence map›Paper›PMID 33330495›Full record

ArticleFrontiers in cell and developmental biology2020

Single Cell Mechanotype and Associated Molecular Changes in Urothelial Cell Transformation and Progression.

Weibo Yu, Qing-Yi Lu, Shivani Sharma, Chau Ly, Dino Di Carlo, Amy C Rowat, Michael LeClaire, Donghyuk Kim, Christine Chow, James K Gimzewski and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cell and developmental biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.9field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
  2. Article
  3. Characterization of Breast Cancer Aggressiveness by Cell Mechanics.International journal of molecular sciences · 2023
    Article
  4. Article
  5. Review
  6. Article
  7. Cancer cell mechanobiology: a new frontier for cancer research.Journal of the National Cancer Center · 2022
    Review
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Weibo YuDepartment of Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, CA, United States.
Qing-Yi LuDepartment of Medicine, University of California, Los Angeles, Los Angeles, CA, United States.
Shivani SharmaDepartment of Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, CA, United States.
Chau LyDepartment of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, CA, United States.
Dino Di CarloDepartment of Bioengineering, University of California, Los Angeles, Los Angeles, CA, United States.
Amy C RowatDepartment of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, CA, United States.
Michael LeClaireDepartment of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA, United States.
Donghyuk KimDepartment of Bioengineering, University of California, Los Angeles, Los Angeles, CA, United States.
Christine ChowDepartment of Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, CA, United States.
James K GimzewskiDepartment of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA, United States.
Jianyu RaoDepartment of Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, CA, United States.
University of California, Los Angeles · US

Funding

UCLA SPORE in Brain CancerP50CA211015 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI David A. Nathanson · 2017 to 2026
$25.2M
Cancer Cell Mechanical Profiling AnalysisR21CA208196 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI RAO, JIANYU · 2017 to 2018
$372k
NCI NIH HHS P50 CA211015NCI NIH HHS R21 CA208196
6 · The paper itself

Abstract

Cancer cell mechanotype changes are newly recognized cancer phenotypic events, whereas metastatic cancer cells show decreased cell stiffness and increased deformability relative to normal cells. To further examine how cell mechanotype changes in early stages of cancer transformation and progression, an

Indexed as

bladder cancercancer progressioncell deformabilitycell mechanotypecell stiffnessEMT

Identifiers

PMID33330495
PMCPMC7711308
OpenAlexW3109442249

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.