Evidence map›Paper›PMID 33330433›Full record

ArticleFrontiers in bioengineering and biotechnology2020

Real-Time Fast Scan Cyclic Voltammetry Detection and Quantification of Exogenously Administered Melatonin in Mice Brain.

Elisa Castagnola, Elaine M Robbins, Kevin M Woeppel, Moriah McGuier, Asiyeh Golabchi, I Mitch Taylor, Adrian C Michael, Xinyan Tracy Cui

Open access · goldAbstract read
In one paragraph

Article in Frontiers in bioengineering and biotechnology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 39 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Elisa CastagnolaDepartment of Bioengineering, University of Pittsburgh, Pittsburgh, PA, United States.
Elaine M RobbinsDepartment of Bioengineering, University of Pittsburgh, Pittsburgh, PA, United States.
Kevin M WoeppelDepartment of Bioengineering, University of Pittsburgh, Pittsburgh, PA, United States.
Moriah McGuierDepartment of Chemistry, Saint Vincent College, Latrobe, PA, United States.
Asiyeh GolabchiDepartment of Bioengineering, University of Pittsburgh, Pittsburgh, PA, United States.
I Mitch TaylorDepartment of Chemistry, Saint Vincent College, Latrobe, PA, United States.
Adrian C MichaelDepartment of Chemistry, University of Pittsburgh, Pittsburgh, PA, United States.
Xinyan Tracy CuiDepartment of Bioengineering, University of Pittsburgh, Pittsburgh, PA, United States.
University of Pittsburgh · USCenter for the Neural Basis of Cognition · USSaint Vincent College · US

Funding

Improving chronic neural recording performance through biomaterial strategiesR01NS062019 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CUI, XINYAN TRACY · 2008 to 2018
$4.4M
Inhibition of Neural Electrode-mediated Inflammation and Neuronal Cell DeathR01NS089688 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CUI, XINYAN TRACY · 2015 to 2019
$3.1M
Ultra sensitive and flexible MEAs for chronic dopamine detection at both tonic and phasic levelsR21DA049592 · NIDA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CUI, XINYAN TRACY · 2019 to 2020
$428k
Dual Polymer Coatings for High Fidelity and Stable In Vivo Cocaine Sensing From MEAsR21DA043817 · NIDA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CUI, XINYAN TRACY · 2017 to 2018
$421k
NIDA NIH HHS R21 DA043817NIDA NIH HHS R21 DA049592NINDS NIH HHS R01 NS062019NINDS NIH HHS R01 NS089688
6 · The paper itself

Abstract

Melatonin (MT) has been recently considered an excellent candidate for the treatment of sleep disorders, neural injuries, and neurological diseases. To better investigate the actions of MT in various brain functions, real-time detection of MT concentrations in specific brain regions is much desired. Previously, we have demonstrated detection of exogenously administered MT in anesthetized mouse brain using square wave voltammetry (SWV). Here, for the first time, we show successful detection of exogenous MT in the brain using fast scan cyclic voltammetry (FSCV) on electrochemically pre-activated carbon fiber microelectrodes (CFEs).

Indexed as

braincarbon fiber microelectrodeselectrochemical impedance spectroscopyfast scan cyclic voltammetryfoulingmelatonin

Identifiers

PMID33330433
PMCPMC7732424
OpenAlexW3110405104

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.