Evidence map›Paper›PMID 33330372›Full record

ArticleFrontiers in chemistry2020

Novel Leu-Val Based Dipeptide as Antimicrobial and Antimalarial Agents: Synthesis and Molecular Docking.

James A Ezugwu, Uchechukwu C Okoro, Mercy A Ezeokonkwo, China R Bhimapaka, Sunday N Okafor, David I Ugwu, Ogechi C Ekoh, Solomon I Attah

Open access · goldAbstract read
In one paragraph

Article in Frontiers in chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.3field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

James A EzugwuDepartment of Pure and Industrial Chemistry, University of Nigeria, Nsukka, Nigeria.
Uchechukwu C OkoroDepartment of Pure and Industrial Chemistry, University of Nigeria, Nsukka, Nigeria.
Mercy A EzeokonkwoDepartment of Pure and Industrial Chemistry, University of Nigeria, Nsukka, Nigeria.
China R BhimapakaOrganic Synthesis and Process Chemistry, Council for Scientific and Industrial Research-India Institute of Chemical Technology, Hyderabad, India.
Sunday N OkaforDepartment of Pharmaceutical and Medicinal Chemistry, University of Nigeria, Nsukka, Nigeria.
David I UgwuDepartment of Pure and Industrial Chemistry, University of Nigeria, Nsukka, Nigeria.
Ogechi C EkohDepartment of Industrial Chemistry, Evangel University Akaeze, Enugu, Nigeria.
Solomon I AttahDepartment of Pure and Industrial Chemistry, University of Nigeria, Nsukka, Nigeria.
University of Nigeria · NGIndian Institute of Chemical Technology · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The increase of antimicrobial resistance (AMR) and antimalarial resistance are complex and severe health issues today, as many microbial strains have become resistant to market drugs. The choice for the synthesis of new dipeptide-carboxamide derivatives is as a result of their wide biological properties such as antimicrobial, anti-inflammatory, and antioxidant activities. The condensation reaction of substituted benzenesulphonamoyl pentanamides with the carboxamide derivatives using peptide coupling reagents gave targeted products (

Indexed as

antimalarialantimicrobialbenzenesulfonamidein silico studiesLeu-Val dipeptide

Identifiers

PMID33330372
PMCPMC7732421
OpenAlexW3107020332

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.