ReviewFrontiers in cellular and infection microbiology2020
The Use of Adjunctive Steroids in Central Nervous Infections.
Review in Frontiers in cellular and infection microbiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it, 62 citations in OpenAlex.
- Clinical and Laboratory Predictors of Poor Neurological Outcomes Following Infectious Encephalitis: Systematic Review and Meta-Analysis.European journal of neurology · 2025Pooled it
- Clofazimine against cerebral toxoplasmosis in diabetic and dexamethasone-immunosuppressed mice: ultrastructural and semiquantitative transmission electron microscopic study.BMC neuroscience · 2026Article
- Meningoencephalitis in Flea-Borne Typhus: A Report of Two Cases and a Review of CNS Complications.Pathogens (Basel, Switzerland) · 2026Review
- Corticosteroids as adjunctive therapy in acute meningitis: a narrative review.Annals of medicine and surgery (2012) · 2026Review
- An overview on central nervous system tuberculosis (CNS-TB) focusing on cognitive impairments.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas · 2026Review
- Tunnel sign on magnetic resonance imaging in neuromelioidosis: A systematic literature review.New microbes and new infections · 2025Review
- Antimicrobial Resistance and the Blood-Brain Barrier: Complex Interactions and Implications for Neurological Health.Molecular neurobiology · 2025Review
- Solitary thalamic abscess without meningitis from Coccidioides immitis: illustrative case.Journal of neurosurgery. Case lessons · 2025Article
- A relapse of acute group B streptococcus meningitis in a healthy adult: Case report and review of the literatures.Journal of general and family medicine · 2025Article
- Management of pott's puffy tumor: a Delphi-method international clinical consensus statement.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2025Article
- Steroidomic Changes in the Cerebrospinal Fluid of Women with Multiple Sclerosis.International journal of molecular sciences · 2025Article
- Tuberculous hemorrhagic meningoencephalitis. A rare manifestation of miliary TB. Case report and review.Radiology case reports · 2025Article
- Peri-operative anti-inflammatory drug use and seizure recurrence after resective epilepsy surgery: Target trials emulation.iScience · 2025Article
- Inflammatory markers in cerebrospinal fluid in pediatric Brazilian spotted fever with neurological manifestations.Revista do Instituto de Medicina Tropical de Sao Paulo · 2025Article
- Case Report: MOGAD - a steroid-responsive autoimmune meningoencephalitis mimicking infection.Frontiers in immunology · 2025Article
- The Role of Corticosteroids in Non-Bacterial and Secondary Encephalitis.Life (Basel, Switzerland) · 2024Review
- Risk Prediction and Management for Central Nervous System Infection After Resection for Gliomas-The 8-Year Experience from a Tertiary Medical Center.Journal of clinical medicine · 2024Article
- Treating acute encephalitis.Intensive care medicine · 2024Article
- Outbreak ofOpen forum infectious diseases · 2024Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Central nervous system (CNS) infections continue to be associated with significant neurological morbidity and mortality despite various existing therapies. Adjunctive steroid therapy has been employed clinically to reduce inflammation in the treatment of CNS infections across various causative pathogens. Steroid therapy can potentially improve clinical outcomes including reducing mortality rates, provide no significant benefit, or cause worsened outcomes, based on the causative agent of infection. The data on benefits or harms of adjunctive steroid therapy is not consistent in outcome or density through CNS infections, and varies based on the disease diagnosis and pathogen. We summarize the existing literature on the effects of adjunctive steroid therapy on outcome for a number of CNS infections, including bacterial meningitis, herpes simplex virus, West Nile virus, tuberculosis meningitis, cryptococcal meningitis,
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.