Evidence map›Paper›PMID 33330125›Full record

ArticleFrontiers in cellular and infection microbiology2020

Emergence of Multidrug Resistant Hypervirulent ST23

Chaitra Shankar, Jobin John Jacob, Karthick Vasudevan, Rohit Biswas, Abi Manesh, Dhiviya Prabaa Muthuirulandi Sethuvel, Santosh Varughese, Indranil Biswas, Balaji Veeraraghavan

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 1 pooled it
2.2field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.

  1. Pathogens (Basel, Switzerland) · 2024
    Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. HypervirulentPharmaceuticals (Basel, Switzerland) · 2025
    Review
  10. Emergence ofMicrobiology spectrum · 2025
    Article
  11. Clinical and genomic characterization ofFrontiers in microbiology · 2025
    Article
  12. The poly (A) polymeraseFrontiers in microbiology · 2025
    Article
  13. Review
  14. Article
  15. A Comprehensive Overview ofInfection and drug resistance · 2025
    Review
  16. Article
  17. Article
  18. Virulence Factors inIndian journal of microbiology · 2024
    Review
  19. Article
  20. Clinical and Genomic Characterization of a Cohort of Patients With Klebsiella pneumoniae Bloodstream Infection.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Chaitra ShankarDepartment of Clinical Microbiology, Christian Medical College and Hospital, Vellore, India.
Jobin John JacobDepartment of Clinical Microbiology, Christian Medical College and Hospital, Vellore, India.
Karthick VasudevanDepartment of Clinical Microbiology, Christian Medical College and Hospital, Vellore, India.
Rohit BiswasCollege of Biological Sciences, University of Minnesota, Saint Paul, MN, United States.
Abi ManeshDepartment of Infectious Diseases, Christian Medical College and Hospital, Vellore, India.
Dhiviya Prabaa Muthuirulandi SethuvelDepartment of Clinical Microbiology, Christian Medical College and Hospital, Vellore, India.
Santosh VarugheseDepartment of Nephrology, Christian Medical College and Hospital, Vellore, India.
Indranil BiswasDepartment of Microbiology, Molecular Genetics and Immunology, University of Kansas Medical Centre, Kansas City, KS, United States.
Balaji VeeraraghavanDepartment of Clinical Microbiology, Christian Medical College and Hospital, Vellore, India.
Christian Medical College & Hospital · INUniversity of Kansas Medical Center · USUniversity of Minnesota · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: In recent years, the emergence of multidrug resistant hypervirulent Methods: Two hvKp isolates from patients with bacteremia were sequenced using Ion Torrent PGM and Oxford Nanopore MinION platforms and assembled by hybrid genome assembly approach. Comparative genomics approaches were used to investigate the population structure, evolution, virulence, and antimicrobial resistance of MDR hvKp strains. Results: The study isolates exhibited typical features of hvKp phenotypes associated with ST23. The convergence of multidrug resistance and hypervirulence were attributed by the presence of multiple plasmids including a 216 kb virulence plasmid and MDR plasmids belonging to IncA/C Conclusion: To the best of our knowledge, this is the first report of MDR hvKp isolates of ST23 with insertion of

Indexed as

Klebsiella InfectionsKlebsiella pneumoniaeBacterial ProteinsHumansPhylogenyPlasmidsBacterial Proteinshybrid genomehypervirulence plasmidKlebsiella pneumoniaemultidrug resistanceOXA-232ST23

Identifiers

PMID33330125
PMCPMC7718023
OpenAlexW3109069107

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.