ArticleFrontiers in oncology2020
Isotropic Expansion of the Intraprostatic Gross Tumor Volume of Primary Prostate Cancer Patients Defined in MRI-A Correlation Study With Whole Mount Histopathological Information as Reference.
Article in Frontiers in oncology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.
- Focal radiation therapies for localized prostate cancer: a systematic review of clinical evidence and outcomes.Prostate cancer and prostatic diseases · 2026Pooled it
- Histopathology-validated gross tumor volume delineations of intraprostatic lesions using PSMA-positron emission tomography/multiparametric magnetic resonance imaging.Physics and imaging in radiation oncology · 2024Article
- Advantage of whole-mount histopathology in prostate cancer: current applications and future prospects.BMC cancer · 2024Review
- Explainable AI for CNN-based prostate tumor segmentation in multi-parametric MRI correlated to whole mount histopathology.Radiation oncology (London, England) · 2022Article
- Tumour growth rates of prostate cancer during active surveillance: is there a difference between MRI-visible low and intermediate-risk disease?The British journal of radiology · 2022Article
- Intraindividual Comparison Between [Frontiers in oncology · 2022Article
- Article
- Target Volume Optimization for Localized Prostate Cancer.Practical radiation oncologyReview
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Authors and funding
13 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionAn accurate delineation of the intraprostatic gross tumor volume (GTV) is of importance for focal treatment in patients with primary prostate cancer (PCa). Multiparametric MRI (mpMRI) is the standard of care for lesion detection but has been shown to underestimate GTV. This study investigated how far the GTV has to be expanded in MRI in order to reach concordance with the histopathological reference and whether this strategy is practicable in clinical routine. PATIENTS AND
methodsTwenty-two patients with planned prostatectomy and preceded 3 Tesla mpMRI were prospectively examined. After surgery, PCa contours delineated on histopathological slides (GTV-Histo) were superimposed on MRI using
resultsIn 19 of 22 patients MRI underestimated the intraprostatic tumor volume compared to histopathological reference: median GTV-Histo (4.7 cm
conclusionUsing histopathology as reference, we demonstrated that MRI underestimates intraprostatic tumor volume. A 2 mm-expansion may improve accurate GTV-delineation while respecting the balance between histological tumor coverage and overtreatment.
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