Evidence map›Paper›PMID 33329939›Full record

ArticleOncoimmunology2020

Loss of p27Kip1 leads to expansion of CD4+ effector memory T cells and accelerates colitis-associated colon cancer in mice with a T cell lineage restricted deletion of Smad4.

Sung Hee Choi, Emily C Barker, Kyle J Gerber, John J Letterio, Byung-Gyu Kim

Open access · goldAbstract read
In one paragraph

Article in Oncoimmunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.7field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 23 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Sung Hee ChoiDepartment of Pediatrics, Case Western Reserve University, Cleveland, OH, USA.
Emily C BarkerDepartment of Pediatrics, Case Western Reserve University, Cleveland, OH, USA.
Kyle J GerberDepartment of Chemistry, Case Western Reserve University, Cleveland, Ohio, USA.
John J LetterioDepartment of Pediatrics, Case Western Reserve University, Cleveland, OH, USA.
Byung-Gyu KimDepartment of Pediatrics, Case Western Reserve University, Cleveland, OH, USA.ORCID 0000-0002-8921-5061
Case Western Reserve University · USRainbow Babies & Children's Hospital · US

Funding

RESEARCH ONCOLOGY TRAINING GRANTT32CA059366 · NCI · CASE WESTERN RESERVE UNIVERSITY · PI JACKSON, MARK W. · 1993 to 2025
$5.5M
Small Molecule Induction of 15-PGDH: A Target in Colon Cancer ChemopreventionR01CA168586 · NCI · CASE WESTERN RESERVE UNIVERSITY · PI LETTERIO, JOHN JAMES · 2013 to 2017
$1.6M
NCI NIH HHS R01 CA168586NCI NIH HHS T32 CA059366
6 · The paper itself

Abstract

The cyclin-dependent kinase inhibitor p27

Indexed as

Colitis-Associated NeoplasmsImmunologic MemoryAnimalsCD4-Positive T-LymphocytesCell LineageCyclin-Dependent Kinase Inhibitor p27MiceCyclin-Dependent Kinase Inhibitor p27CD4 effector T cellcolitis-associated colon cancerp27kip1Smad4

Identifiers

PMID33329939
PMCPMC7722707
OpenAlexW3107548823

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.