Evidence map›Paper›PMID 33329827›Full record

ArticleAnesthesia and pain medicine2020

Effects of tranexamic acid on the activity of glutamate transporter EAAT3.

Hyun-Jung Shin, Soo-Young Lee, Hyo-Seok Na, Bon-Wook Koo, Jung-Hee Ryu, Sang-Hwan Do

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Anesthesia and pain medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 54% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Hyun-Jung ShinDepartment of Anesthesiology and Pain Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.ORCID 0000-0003-0991-7061
Soo-Young Lee2Department of Anesthesiology and Pain Medicine, ThanQ Seoul Thyroid-Head & Neck Surgery Center, Seoul, Korea.ORCID 0000-0002-2053-0055
Hyo-Seok NaDepartment of Anesthesiology and Pain Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.ORCID 0000-0003-0986-3243
Bon-Wook KooDepartment of Anesthesiology and Pain Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.ORCID 0000-0001-5311-8115
Jung-Hee RyuDepartment of Anesthesiology and Pain Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.ORCID 0000-0001-9331-5658
Sang-Hwan DoDepartment of Anesthesiology and Pain Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.ORCID 0000-0001-5452-4166
Seoul National University Bundang Hospital · KRSeoul Medical Center · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTranexamic acid (TXA) is the most widely used hemostatic agent in surgical patients. However, when used in a high dose, it could cause a seizure in the postoperative period. The exact effector mechanism behind the seizure triggering remains unknown. Therefore, the authors investigated the effects of TXA on the activity of glutamate transporter type 3 (excitatory amino acid transporter 3; EAAT3), which is the main neuronal glutamate transporter type.

methodsEAAT3 was expressed in

resultsTXA (30 to 1,000 µM) significantly decreased EAAT3 activity. Our kinetic study showed that V

conclusionsOur results suggest that TXA attenuates EAAT3 activity, which may explain its proconvulsant effect.

Indexed as

ElectrophysiologyExcitatory amino acid transporter 3Glutamate plasma membrane transport proteinsTranexamic acidXenopus laevis

Identifiers

PMID33329827
PMCPMC7713840
OpenAlexW3035989878

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.