Evidence map›Paper›PMID 33329709›Full record

ArticleFrontiers in genetics2020

Effects of Genetic Polymorphisms of Drug Transporter ABCB1 (MDR1) and Cytochrome P450 Enzymes CYP2A6, CYP2B6 on Nicotine Addiction and Smoking Cessation.

Ahmet Muderrisoglu, Elif Babaoglu, Elif Tugce Korkmaz, Mert C Ongun, Erdem Karabulut, Alper B Iskit, Salih Emri, Melih O Babaoglu

Open access · goldAbstract read
In one paragraph

Article in Frontiers in genetics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Ahmet MuderrisogluDepartment of Pharmacology, Faculty of Medicine, Hacettepe University, Ankara, Turkey.
Elif BabaogluDepartment of Chest Diseases, Faculty of Medicine, Hacettepe University, Ankara, Turkey.
Elif Tugce KorkmazDepartment of Chest Diseases, Faculty of Medicine, Hacettepe University, Ankara, Turkey.
Mert C OngunDepartment of Pharmacology, Faculty of Medicine, Hacettepe University, Ankara, Turkey.
Erdem KarabulutDepartment of Biostatistics, Faculty of Medicine, Hacettepe University, Ankara, Turkey.
Alper B IskitDepartment of Pharmacology, Faculty of Medicine, Hacettepe University, Ankara, Turkey.
Salih EmriDepartment of Chest Diseases, Faculty of Medicine, Hacettepe University, Ankara, Turkey.
Melih O BabaogluDepartment of Pharmacology, Faculty of Medicine, Hacettepe University, Ankara, Turkey.
Hacettepe University · TR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo determine the effects of genetic polymorphisms of ABCB1 (MDR1), CYP2A6, CYP2B6 on smoking status, and clinical outcomes of smoking cessation therapies in a Turkish population.

methods130 smokers and 130 non-smokers were recruited. Individuals who never smoked were described as non-smokers. 130 smokers were treated with nicotine replacement therapy (NRT) (

resultsCessation rates were as follows; 20.0% for NRT, 29.8% for bupropion, 40.0% for bupropion + NRT, 57.1% for varenicline (

conclusionGenetic variants of the drug transporter ABCB1 and the

Indexed as

addictioncytochrome P450 enzymesgenetic polymorphismnicotineP-glycoprotein

Identifiers

PMID33329709
PMCPMC7734344
OpenAlexW3106922941

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.