Evidence map›Paper›PMID 33329587›Full record

ArticleFrontiers in immunology2020

Dynamics of Transforming Growth Factor (TGF)-β Superfamily Cytokine Induction During HIV-1 Infection Are Distinct From Other Innate Cytokines.

Matthew Dickinson, Anna E Kliszczak, Eleni Giannoulatou, Dimitra Peppa, Pierre Pellegrino, Ian Williams, Hal Drakesmith, Persephone Borrow

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 40 citations in OpenAlex.

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  15. FoxP3Frontiers in immunology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 2 countries.

Matthew DickinsonNuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom.
Anna E KliszczakNuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom.
Eleni GiannoulatouComputational Genomics Laboratory, Victor Chang Cardiac Research Institute, Sydney, NSW, Australia.
Dimitra PeppaNuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom.
Pierre PellegrinoCentre for Sexual Health and HIV Research, University College London, London, United Kingdom.
Ian WilliamsCentre for Sexual Health and HIV Research, University College London, London, United Kingdom.
Hal DrakesmithMRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, United Kingdom.
Persephone BorrowNuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom.
MRC Weatherall Institute of Molecular Medicine · GBUniversity College London · GBUniversity of Oxford · GBMortimer Market Centre · GBSt Vincent's Clinic · AU

Funding

Restriction of HIV-1 transmission by type 1 interferonsR01AI114266 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI HAHN, BEATRICE H · 2014 to 2018
$3.2M
Medical Research Council MC_UU_00008/10Medical Research Council MC_UU_12010/10Medical Research Council MR/K012037/1Medical Research Council MR/M008614/2NIAID NIH HHS R01 AI114266
6 · The paper itself

Abstract

Human immunodeficiency virus type 1 (HIV-1) infection triggers rapid induction of multiple innate cytokines including type I interferons, which play important roles in viral control and disease pathogenesis. The transforming growth factor (TGF)-β superfamily is a pleiotropic innate cytokine family, some members of which (activins and bone morphogenetic proteins (BMPs)) were recently demonstrated to exert antiviral activity against Zika and hepatitis B and C viruses but are poorly studied in HIV-1 infection. Here, we show that TGF-β

Indexed as

Immunity, InnateBiomarkersCytokinesDendritic CellsHIV-1HIV InfectionsHost-Pathogen InteractionsHumansTransforming Growth Factor betaBiomarkersCytokinesTransforming Growth Factor betaactivinbone morphogenetic proteincytokinedendritic cellHIVinnate responseinterferonTGF-beta

Identifiers

PMID33329587
PMCPMC7732468
OpenAlexW3099257908

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.