Evidence map›Paper›PMID 33329430›Full record

ArticleFrontiers in microbiology2020

Gut Microbiome Contributes to Liver Fibrosis Impact on T Cell Receptor Immune Repertoire.

Qing Liang, Meina Zhang, Yudi Hu, Wei Zhang, Ping Zhu, Yujie Chen, Pengxin Xue, Qiyuan Li, Kejia Wang

Open access · goldAbstract read
In one paragraph

Article in Frontiers in microbiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
2.0field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 28 citations in OpenAlex.

  1. Article
  2. Article
  3. The bile acid-gut microbiota-vitamin D axis: new insights into biliary atresia.Frontiers in cellular and infection microbiology · 2026
    Review
  4. Review
  5. Article
  6. Review
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Review
  16. Review
  17. Review
  18. Article
  19. Review
  20. Omics in gut microbiome analysis.Journal of microbiology (Seoul, Korea) · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Qing LiangNational Institute for Data Science in Health and Medicine, School of Medicine, Xiamen University, Xiamen, China.
Meina ZhangNational Institute for Data Science in Health and Medicine, School of Medicine, Xiamen University, Xiamen, China.
Yudi HuNational Institute for Data Science in Health and Medicine, School of Medicine, Xiamen University, Xiamen, China.
Wei ZhangDepartment of Pathology, The 971 Hospital of People's Liberation Army Navy, Qingdao, China.
Ping ZhuDepartment of Gynecology and Obstetrics, The 971 Hospital of People's Liberation Army Navy, Qingdao, China.
Yujie ChenNational Institute for Data Science in Health and Medicine, School of Medicine, Xiamen University, Xiamen, China.
Pengxin XueNational Institute for Data Science in Health and Medicine, School of Medicine, Xiamen University, Xiamen, China.
Qiyuan LiNational Institute for Data Science in Health and Medicine, School of Medicine, Xiamen University, Xiamen, China.
Kejia WangNational Institute for Data Science in Health and Medicine, School of Medicine, Xiamen University, Xiamen, China.
Xiamen University · CNPeople's Liberation Army 401 Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gut microbiota (GM) modifies the intrahepatic immune microenvironment, but the underlying mechanisms remain poorly understood. Liver fibrosis-associated imprinting is predicted to be reflected in GM. This study investigated the link between GM and the intrahepatic T cell receptor (TCR) immune repertoire (IR), and whether GM modulates the intrahepatic immune microenvironment via TCR IR during liver fibrosis. We analyzed the correlation between GM and TCR IR during liver fibrogenesis. Accordingly, 16S rRNA gene sequencing (16S-seq) and bulk immune repertoire sequencing (IR-seq) were performed to characterize GM and intrahepatic TCR IR. Fecal microbial transplant (FMT) and TCRβ knockout (Tcrb

Indexed as

gut microbiomeimmune microenvironmentimmune repertoireliver fibrosisT cell receptor

Identifiers

PMID33329430
PMCPMC7729130
OpenAlexW3108618660

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.