Evidence map›Paper›PMID 33329316›Full record

ArticleFrontiers in neurology2020

RNA Sequencing of Human Peripheral Blood Cells Indicates Upregulation of Immune-Related Genes in Huntington's Disease.

Miguel A Andrade-Navarro, Katja Mühlenberg, Eike J Spruth, Nancy Mah, Adrián González-López, Tommaso Andreani, Jenny Russ, Matthew R Huska, Enrique M Muro, Jean-Fred Fontaine and 5 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in neurology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.6field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
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  3. Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. A Glimpse of Molecular Biomarkers in Huntington's Disease.International journal of molecular sciences · 2022
    Review
  11. Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 6 institutions in 2 countries.

Miguel A Andrade-NavarroFaculty of Biology, Institute of Organismic and Molecular Evolution, Johannes Gutenberg University Mainz, Mainz, Germany.
Katja MühlenbergNeuroproteomics, Max-Delbrück Center for Molecular Medicine, Berlin, Germany.
Eike J SpruthDepartment of Neuropsychiatry, Charité-Universitätsmedizin Berlin, Berlin, Germany.
Nancy MahCharité-Universitätsmedizin Berlin, Virchow-Klinikum, Berlin-Brandenburger Centrum für Regenerative Therapien, Berlin, Germany.
Adrián González-LópezKlinik f. Anästhesiologie m.S. operative Intensivmedizin, Virchow Klinikum, Charité-Universitätsmedizin Berlin, Berlin, Germany.
Tommaso AndreaniFaculty of Biology, Institute of Organismic and Molecular Evolution, Johannes Gutenberg University Mainz, Mainz, Germany.
Jenny RussGerman Center for Neurodegenerative Diseases, Bonn, Germany.
Matthew R HuskaDepartment for Computational Molecular Biology, Max Planck Institute for Molecular Genetics, Berlin, Germany.
Enrique M MuroFaculty of Biology, Institute of Organismic and Molecular Evolution, Johannes Gutenberg University Mainz, Mainz, Germany.
Jean-Fred FontaineFaculty of Biology, Institute of Organismic and Molecular Evolution, Johannes Gutenberg University Mainz, Mainz, Germany.
Vyacheslav AmstislavskiyMax-Planck-Institute for Molecular Genetics, Berlin, Germany.
Alexei SoldatovMax-Planck-Institute for Molecular Genetics, Berlin, Germany.
Wilfried NietfeldMax-Planck-Institute for Molecular Genetics, Berlin, Germany.
Erich E WankerNeuroproteomics, Max-Delbrück Center for Molecular Medicine, Berlin, Germany.
Josef PrillerDepartment of Neuropsychiatry, Charité-Universitätsmedizin Berlin, Berlin, Germany.
Johannes Gutenberg University Mainz · DEMax Planck Institute for Molecular Genetics · DECharité - Universitätsmedizin Berlin · DEMax Delbrück Center · DEGerman Center for Neurodegenerative Diseases · DEUK Dementia Research Institute · GB

Funding

Medical Research Council MC_PC_16031
6 · The paper itself

Abstract

Huntington's disease (HD) is an autosomal dominantly inherited neurodegenerative disorder caused by a trinucleotide repeat expansion in the

Indexed as

differential gene expressiondisease markersHuntington's diseaseinflammationRNA-Seq

Identifiers

PMID33329316
PMCPMC7731869
OpenAlexW3107525900

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.