Evidence map›Paper›PMID 33329127›Full record

ArticleFrontiers in psychiatry2020

Maturation of Auditory Cortex Neural Activity in Children and Implications for Auditory Clinical Markers in Diagnosis.

J Christopher Edgar, Lisa Blaskey, Heather L Green, Kimberly Konka, Guannan Shen, Marissa A Dipiero, Jeffrey I Berman, Luke Bloy, Song Liu, Emma McBride and 7 more

Abstract read
In one paragraph

Article in Frontiers in psychiatry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Lower Cortical Activation and Altered Functional Connectivity Characterize Passive Auditory Spatial Attention in ASD.Autism research : official journal of the International Society for Autism Research · 2025
    Article
  5. Article
  6. Article
  7. Article
  8. Functional and structural maturation of auditory cortex from 2 months to 2 years old.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2024
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

J Christopher EdgarDepartment of Radiology, Lurie Family Foundations Magnetoencephalography Imaging Center, The Children's Hospital of Philadelphia, Philadelphia, PA, United States.
Lisa BlaskeyDepartment of Radiology, Lurie Family Foundations Magnetoencephalography Imaging Center, The Children's Hospital of Philadelphia, Philadelphia, PA, United States.
Heather L GreenDepartment of Radiology, Lurie Family Foundations Magnetoencephalography Imaging Center, The Children's Hospital of Philadelphia, Philadelphia, PA, United States.
Kimberly KonkaDepartment of Radiology, Lurie Family Foundations Magnetoencephalography Imaging Center, The Children's Hospital of Philadelphia, Philadelphia, PA, United States.
Guannan ShenDepartment of Radiology, Lurie Family Foundations Magnetoencephalography Imaging Center, The Children's Hospital of Philadelphia, Philadelphia, PA, United States.
Marissa A DipieroDepartment of Radiology, Lurie Family Foundations Magnetoencephalography Imaging Center, The Children's Hospital of Philadelphia, Philadelphia, PA, United States.
Jeffrey I BermanDepartment of Radiology, Lurie Family Foundations Magnetoencephalography Imaging Center, The Children's Hospital of Philadelphia, Philadelphia, PA, United States.
Luke BloyDepartment of Radiology, Lurie Family Foundations Magnetoencephalography Imaging Center, The Children's Hospital of Philadelphia, Philadelphia, PA, United States.
Song LiuDepartment of Radiology, Lurie Family Foundations Magnetoencephalography Imaging Center, The Children's Hospital of Philadelphia, Philadelphia, PA, United States.
Emma McBrideDepartment of Radiology, Lurie Family Foundations Magnetoencephalography Imaging Center, The Children's Hospital of Philadelphia, Philadelphia, PA, United States.
Matt KuDepartment of Radiology, Lurie Family Foundations Magnetoencephalography Imaging Center, The Children's Hospital of Philadelphia, Philadelphia, PA, United States.
Emily S KuschnerDepartment of Radiology, Lurie Family Foundations Magnetoencephalography Imaging Center, The Children's Hospital of Philadelphia, Philadelphia, PA, United States.
Megan AireyDepartment of Radiology, Lurie Family Foundations Magnetoencephalography Imaging Center, The Children's Hospital of Philadelphia, Philadelphia, PA, United States.
Mina KimDepartment of Radiology, Lurie Family Foundations Magnetoencephalography Imaging Center, The Children's Hospital of Philadelphia, Philadelphia, PA, United States.
Rose E FranzenDepartment of Radiology, Lurie Family Foundations Magnetoencephalography Imaging Center, The Children's Hospital of Philadelphia, Philadelphia, PA, United States.
Gregory A MillerDepartment of Psychology, University of California, Los Angeles, Los Angeles, CA, United States.
Timothy P L RobertsDepartment of Radiology, Lurie Family Foundations Magnetoencephalography Imaging Center, The Children's Hospital of Philadelphia, Philadelphia, PA, United States.

Funding

TRANSGENIC MOUSE MODELS OF MENTAL RETARDATIONP30HD026979 · NICHD · CHILDREN'S HOSP OF PHILADELPHIA · PI YUDKOFF, MARC · 1990 to 2015
$15.3M
A longitudinal study of brain development in children with autismR01MH107506 · NIMH · CHILDREN'S HOSP OF PHILADELPHIA · PI James Christopher EDGAR · 2016 to 2026
$7.5M
Brain structure and function in infantsR01HD093776 · NICHD · CHILDREN'S HOSP OF PHILADELPHIA · PI James Christopher EDGAR · 2018 to 2026
$5.7M
Electrophysiological Signatures of Language Impairment in Autism Spectrum DisordeR01DC008871 · NIDCD · CHILDREN'S HOSP OF PHILADELPHIA · PI ROBERTS, TIMOTHY P · 2007 to 2018
$3.6M
NICHD NIH HHS P30 HD026979NICHD NIH HHS R01 HD093776NIDCD NIH HHS R01 DC008871NIMH NIH HHS R01 MH107506
6 · The paper itself

Abstract

Functional brain markers that can inform research on brain abnormalities, and especially those ready to facilitate clinical work on such abnormalities, will need to show not only considerable sensitivity and specificity but enough consistency with respect to developmental course that their validity in individual cases can be trusted. A challenge to establishing such markers may be individual differences in developmental course. The present study examined auditory cortex activity in children at an age when developmental changes to the auditory cortex 50 ms (M50) and 100 ms (M100) components are prominent to better understand the use of auditory markers in pediatric clinical research. MEG auditory encoding measures (auditory evoked fields in response to pure tone stimuli) were obtained from 15 typically developing children 6-8 years old, with measures repeated 18 and 36 months after the initial exam. MEG analyses were conducted in source space (i.e., brain location), with M50 and M100 sources identified in left and right primary/secondary auditory cortex (Heschl's gyrus). A left and right M50 response was observed at all times (Time 1, Time 2, Time 3), with M50 latency (collapsing across hemisphere) at Time 3 (77 ms) 10 ms earlier than Time 1 (87 ms;

Indexed as

auditoryM100M50magnetoencephalography (MEG)maturationpediatric

Identifiers

PMID33329127
PMCPMC7717950

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.