Evidence map›Paper›PMID 33329047›Full record

ReviewFrontiers in physiology2020

Hypercapnia Regulates Gene Expression and Tissue Function.

Masahiko Shigemura, Lynn C Welch, Jacob I Sznajder

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.0field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 13 citations in OpenAlex.

  1. Hypercapnia Effects on Lung Function.Comprehensive Physiology · 2026
    Review
  2. Review
  3. Article
  4. Article
  5. Carbon dioxide and MAPK signalling: towards therapy for inflammation.Cell communication and signaling : CCS · 2023
    Review
  6. Review
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Masahiko ShigemuraDivision of Pulmonary and Critical Care Medicine, Northwestern University, Chicago, IL, United States.
Lynn C WelchDivision of Pulmonary and Critical Care Medicine, Northwestern University, Chicago, IL, United States.
Jacob I SznajderDivision of Pulmonary and Critical Care Medicine, Northwestern University, Chicago, IL, United States.
Northwestern University · US

Funding

Role of LUBAC and Na K-ATPase in Acute Lung InjuryP01HL071643 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI SZNAJDER, JACOB I · 2003 to 2019
$30.8M
Role of hypercapnia on the lung airwaysR01HL147070 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI SZNAJDER, JACOB I · 2019 to 2022
$1.9M
NHLBI NIH HHS P01 HL071643NHLBI NIH HHS R01 HL147070
6 · The paper itself

Abstract

Carbon dioxide (CO

Indexed as

carbon dioxidecellular and tissue functionhypercapniainnate immune systemlungskeletal musclestranscriptional regulation

Identifiers

PMID33329047
PMCPMC7715027
OpenAlexW3107647616

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.