Evidence map›Paper›PMID 33329033›Full record

ArticleFrontiers in physiology2020

Effects of Different Exercise Training Protocols on Gene Expression of Rac1 and PAK1 in Healthy Rat Fast- and Slow-Type Muscles.

Saara Laine, Heidi Högel, Tamiko Ishizu, Jussi Toivanen, Minna Yli-Karjanmaa, Tove J Grönroos, Juha Rantala, Rami Mäkelä, Jarna C Hannukainen, Kari K Kalliokoski and 1 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.1field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 citations in OpenAlex.

  1. Trial
  2. Exercise-induced cardiac hypertrophy: cellular and molecular mechanisms of cardiac adaptation following physical activity.Postepy w kardiologii interwencyjnej = Advances in interventional cardiology · 2026
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Saara LaineTurku PET Centre, Turku University Hospital, University of Turku, Turku, Finland.
Heidi HögelTurku Centre for Biotechnology, University of Turku, Åbo Akademi University, Turku, Finland.
Tamiko IshizuTurku PET Centre, Turku University Hospital, University of Turku, Turku, Finland.
Jussi ToivanenTurku PET Centre, Turku University Hospital, University of Turku, Turku, Finland.
Minna Yli-KarjanmaaTurku PET Centre, Turku University Hospital, University of Turku, Turku, Finland.
Tove J GrönroosTurku PET Centre, Turku University Hospital, University of Turku, Turku, Finland.
Juha RantalaMisvik Biology, Turku, Finland.
Rami MäkeläMisvik Biology, Turku, Finland.
Jarna C HannukainenTurku PET Centre, Turku University Hospital, University of Turku, Turku, Finland.
Kari K KalliokoskiTurku PET Centre, Turku University Hospital, University of Turku, Turku, Finland.
Ilkka HeinonenTurku PET Centre, Turku University Hospital, University of Turku, Turku, Finland.
Turku PET Centre · FITurku Centre for Biotechnology · FIUniversity of Turku · FITurku University Hospital · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeRac1 and its downstream target PAK1 are novel regulators of insulin and exercise-induced glucose uptake in skeletal muscle. However, it is not yet understood how different training intensities affect the expression of these proteins. Therefore, we studied the effects of

methodsThe mRNA expression was determined using qPCR and protein expression levels with reverse-phase protein microarray (RPPA).

resultsHIIT significantly

conclusionOur results indicate that HIIT, but not MICT,

Indexed as

exerciseglucose uptakeHIITMICTPAK1Rac1RPPAskeletal muscle

Identifiers

PMID33329033
PMCPMC7711069
OpenAlexW3108721497

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.