ArticleFrontiers in neuroscience2020
Carbachol and Nicotine in Prefrontal Cortex Have Differential Effects on Sleep-Wake States.
Article in Frontiers in neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 15 citations in OpenAlex.
- Article
- Current and Developing Approaches for Facilitating Emergence from General Anesthesia.Anesthesiology · 2025Review
- Sleep circuits welcome the cortex.Sleep · 2025Article
- Article
- Dopaminergic psychostimulants cause arousal from isoflurane-induced sedation without reversing memory impairment in rats.British journal of anaesthesia · 2024Article
- Effect of prolonged sedation with dexmedetomidine, midazolam, propofol, and sevoflurane on sleep homeostasis in rats.British journal of anaesthesia · 2024Article
- Review
- Prefrontal cortex as a key node in arousal circuitry.Trends in neurosciences · 2022Review
- Consciousness, Anesthesia, and Acetylcholine.Anesthesiology · 2021Article
- Inactivation of Prefrontal Cortex Delays Emergence From Sevoflurane Anesthesia.Frontiers in systems neuroscience · 2021Article
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Authors and funding
6 authors at 1 institution in 1 country.
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Abstract
The role of the brainstem cholinergic system in the regulation of sleep-wake states has been studied extensively but relatively little is known about the role of cholinergic mechanisms in prefrontal cortex in the regulation of sleep-wake states. In a recent study, we showed that prefrontal cholinergic stimulation in anesthetized rat can reverse the traits associated with anesthesia and restore a wake-like state, thereby providing evidence for a causal role for prefrontal cholinergic mechanisms in modulating level of arousal. However, the effect of increase in prefrontal cholinergic tone on spontaneous sleep-wake states has yet to be demonstrated. Therefore, in this study, we tested the hypothesis that delivery of cholinergic agonists - carbachol or nicotine - into prefrontal cortex of rat during slow wave sleep (SWS) would produce behavioral arousal and increase the time spent in wake state. We show that unilateral microinjection (200 nL) of carbachol (1 mM) or nicotine (100 mM) into prefrontal cortex during SWS decreased the latency to the onset of wake state (
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