Evidence map›Paper›PMID 33328783›Full record

ArticleActa ortopedica brasileira

IMPROVEMENTS IN HIP OSTEOARTHRITIS WITH LAVAGE, TRIAMCINOLONE AND HYLAN G-F20.

MÁrcia UchÔa DE Rezende, Henrique Melo Campos Gurgel, Guilherme Pereira Ocampos, Gustavo Constantino DE Campos, Renato Frucchi, Alexandre FelÍcio Pailo, Thiago Pasqualin, JosÉ Ricardo Negreiros Vicente, Olavo Pires DE Camargo

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta ortopedica brasileira. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04990128 (Randomized Trial on the Evaluation of the Effectiveness of One Single Bone Marrow Aspirate Hip Injection Versus Triamcinolone for Hip Osteoarthritis), which is not on this map. Cited by 6 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 3 pooled it
1.1field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04990128 phase3not yet recruitingnot on this map

Randomized Trial on the Evaluation of the Effectiveness of One Single Bone Marrow Aspirate Hip Injection Versus Triamcinolone for Hip Osteoarthritis

TypeinterventionalSponsorThe Cleveland ClinicRan2026 to 2027Enrolled100ConditionsHip OsteoarthritisArmsAspire Needle + Emcyte PureBMC, Triamcinolone
3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 3 syntheses or guidelines pooled it, 10 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Review
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

MÁrcia UchÔa DE RezendeUniversidade de São Paulo, Hospital das Clínicas, Medical School, Institute of Orthopedics and Traumatology, São Paulo, SP, Brazil.ORCID 0000-0002-2020-9501
Henrique Melo Campos GurgelUniversidade de São Paulo, Hospital das Clínicas, Medical School, Institute of Orthopedics and Traumatology, São Paulo, SP, Brazil.ORCID 0000-0002-2005-0553
Guilherme Pereira OcamposUniversidade de São Paulo, Hospital das Clínicas, Medical School, Institute of Orthopedics and Traumatology, São Paulo, SP, Brazil.ORCID 0000-0003-0052-6769
Gustavo Constantino DE CamposUniversidade Estadual de Campinas, Campinas, SP, Brazil.ORCID 0000-0001-7811-7354
Renato FrucchiUniversidade de São Paulo, Hospital das Clínicas, Medical School, Institute of Orthopedics and Traumatology, São Paulo, SP, Brazil.ORCID 0000-0003-4601-3846
Alexandre FelÍcio PailoUniversidade de São Paulo, Hospital das Clínicas, Medical School, Institute of Orthopedics and Traumatology, São Paulo, SP, Brazil.ORCID 0000-0002-6547-8940
Thiago PasqualinUniversidade de São Paulo, Hospital das Clínicas, Medical School, Institute of Orthopedics and Traumatology, São Paulo, SP, Brazil.ORCID 0000-0001-9832-1504
JosÉ Ricardo Negreiros VicenteUniversidade de São Paulo, Hospital das Clínicas, Medical School, Institute of Orthopedics and Traumatology, São Paulo, SP, Brazil.ORCID 0000-0003-3528-9249
Olavo Pires DE CamargoUniversidade de São Paulo, Hospital das Clínicas, Medical School, Institute of Orthopedics and Traumatology, São Paulo, SP, Brazil.ORCID 0000-0002-1128-7292
Universidade de São Paulo · BRUniversidade Estadual de Campinas (UNICAMP) · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo verify whether the use of Hylan G-F20 improves saline lavage and triamcinolone injection results in the treatment of hip osteoarthritis (HOA).

methods82 patients with HOA categorized as grades II and III severity, according to Kellgren and Lawrence criteria, were randomized into the groups: lavage and triamcinolone (G0); lavage, triamcinolone, and 2 mL of hylan G-F20 (G1); lavage, triamcinolone, and 4mL of hylan G-F20 (G2); lavage, triamcinolone, and 6mL of hylan G-F20 (G3). The VAS, range of motion (ROM), WOMAC, and Lequesne questionnaires were administered at baseline, one, three, six, and twelve months post-injection.

resultsAll groups showed clinically relevant improvements (> 20%) between baseline and first month post-injection, maintaining subjective results throughout the study period (p < 0.001). We found no differences between groups in any subjective evaluations (p > 0.05, for all). G2 and G3 obtained improved flexion results up to a year (p = 0.028). Hylan groups presented an improved external rotation since the first postoperative month and maintained the results up to a year (G1, p = 0.041; G2, p = 0.007), whereas G0 showed no improvement (p = 0.336).

conclusionHip lavage and triamcinolone injection, with or without the use of hylan, improves pain, function, and quality of life up to a year in HOA. Hylan may improve ROM up to one year.

Indexed as

Hyaluronic AcidMinimal Clinically Important DifferenceOsteoarthritis, HipRandomized Controlled TrialTriamcinoloneViscosupplementation

Identifiers

PMID33328783
PMCPMC7723387
OpenAlexW3111780880

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.