ArticleNature2021
Sorting nexin 5 mediates virus-induced autophagy and immunity.
Open access · greenAbstract read
In one paragraph
Article in Nature, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers.
0numbers the graph read from it
0cells of the map it votes in
66citing papers in PubMed
8.9field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
66 citing papers in PubMed, 95 citations in OpenAlex.
- NS1 of Duck Tembusu Virus Interacts with CCT2: Reduced CCT2 Recovery in LC3C Co-Immunoprecipitation In Vitro and the Proviral Role of CCT2 in DTMUV Infection.Veterinary sciences · 2026Article
- Sorting nexin 5 deficiency impairs MHC class II antigen presentation and inflammatory responses during tuberculosis.Journal of immunology (Baltimore, Md. : 1950) · 2026Article
- Secreted Nonstructural Protein 3 is a Pathogenic Determinant of Orbivirus.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- TRIM21 induces selective autophagy of viruses and bacteria.Molecular cell · 2026Article
- Regulation of Innate Immune Signaling by Autophagy.International journal of molecular sciences · 2026Review
- Nanoadjuvant-integrated organic biomaterials for immune engineering: Mechanisms, design strategies, and translational applications.Materials today. Bio · 2026Review
- The ATG14: multi-layer autophagy control and an emerging therapeutic target in cancer.Apoptosis : an international journal on programmed cell death · 2026Review
- Sorting Nexin 10 Mediates Endosomal Acidification and Autophagy to Promote Influenza A Virus Infection.Viruses · 2026Article
- Sorting nexin 5 mediates antigen presentation and immunity againstbioRxiv : the preprint server for biology · 2026Article
- SNX-3 confers lysosomal fusion-competence to sustain basal autophagy.Cellular and molecular life sciences : CMLS · 2026Article
- Autophagy machinery as exploited by viruses.Autophagy reports · 2025Article
- Physiological roles of phosphoinositides and inositol phosphates: Implications for metabolic dysfunction-associated steatotic liver disease.Clinical science (London, England : 1979) · 2025Review
- SNX10 enhances HCoV-OC43 infection by facilitating viral entry and inhibiting virus-triggered autophagy.Virologica Sinica · 2025Article
- Sorting nexin 3 promotes ischemic retinopathy through RIP1- and RIP3-mediated myeloid cell necroptosis and mitochondrial fission.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Direct pharmacological AMPK activation inhibits mucosal SARS-CoV-2 infection by reducing lipid metabolism, restoring autophagy flux and the type I IFN response.Journal of virology · 2025Article
- The African swine fever virus p22 inhibits the JAK-STAT signaling pathway by promoting the TAX1BP1-mediated degradation of the type I interferon receptor.PLoS pathogens · 2025Article
- Article
- Syntaxin-6 restricts SARS-CoV-2 infection by facilitating virus trafficking to autophagosomes.Journal of virology · 2025Article
- Clofarabine Enhances the Transduction Efficiency of Recombinant AAV2 in the Retina.Investigative ophthalmology & visual science · 2025Article
- Genome-Wide Association Analyses of HPV16 and HPV18 Seropositivity Identify Susceptibility Loci for Cervical Cancer.Journal of medical virology · 2025Article
6 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
Authors and funding
26 authors at 7 institutions in 4 countries.
Xiaonan DongCenter for Autophagy Research, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID http://orcid.org/0000-0001-7967-2755
Yuting YangCenter for Autophagy Research, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Zhongju ZouCenter for Autophagy Research, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Yuting ZhaoCenter for Autophagy Research, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Bo CiQuantitative Biomedical Research Center, Department of Population and Data Sciences, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID http://orcid.org/0000-0003-1721-8076
Lin ZhongQuantitative Biomedical Research Center, Department of Population and Data Sciences, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Madhura BhaveDepartment of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Liwei WangDepartment of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID http://orcid.org/0000-0002-0183-1637
Yi-Chun KuoDepartment of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Xiao ZangQuantitative Biomedical Research Center, Department of Population and Data Sciences, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Rui ZhongQuantitative Biomedical Research Center, Department of Population and Data Sciences, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Elizabeth R AguileraDepartment of Microbiology, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID http://orcid.org/0000-0001-5239-9648
R Blake RichardsonDepartment of Microbiology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Boris SimonettiSchool of Biochemistry, University of Bristol, Bristol, UK.
John W SchogginsDepartment of Microbiology, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID http://orcid.org/0000-0002-7944-6800
Julie K PfeifferDepartment of Microbiology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Li YuThe State Key Laboratory of Membrane Biology, Tsinghua University-Peking University Joint Centre for Life Sciences, School of Life Sciences, Tsinghua University, Beijing, China.
Xuewu ZhangDepartment of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID http://orcid.org/0000-0002-3634-6711
Yang XieQuantitative Biomedical Research Center, Department of Population and Data Sciences, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Sandra L SchmidDepartment of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID http://orcid.org/0000-0002-1690-7024
Guanghua XiaoQuantitative Biomedical Research Center, Department of Population and Data Sciences, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Paul A GleesonDepartment of Biochemistry and Molecular Biology, The University of Melbourne, Melbourne, Victoria, Australia.
Nicholas T KtistakisSignalling Programme, The Babraham Institute, Cambridge, UK.
Peter J CullenSchool of Biochemistry, University of Bristol, Bristol, UK.
Ramnik J XavierCenter for Computational and Integrative Biology, Massachusetts General Hospital, Harvard School of Medicine, Boston, MA, USA. xavier@molbio.mgh.harvard.edu.ORCID http://orcid.org/0000-0002-5630-5167
Beth LevineCenter for Autophagy Research, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA.
The University of Texas Southwestern Medical Center · USHoward Hughes Medical Institute · USUniversity of Bristol · GBBabraham Institute · GBBroad Institute · USPeking University · CNThe University of Melbourne · AU
Funding
RP5: Chemical proteomic discovery of small-molecule probes for autophagy proteinsU19AI142784 · NIAID · UT SOUTHWESTERN MEDICAL CENTER · PI VIRGIN, HERBERT W · 2019 to 2023
$36.9MPilot & Feasibility ProgramP30DK043351 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI RAYMOND T CHUNG · 1991 to 2026
$35.3MGenetic and Pathway Analysis CoreU19AI109725 · NIAID · WASHINGTON UNIVERSITY · PI VIRGIN, HERBERT W · 2014 to 2018
$32.7MATG16L1 T300A: genetics to biologyR01DK097485 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI XAVIER, RAMNIK J · 2013 to 2021
$4.1MTransmembrane signaling mechanisms of plexin - SupplementR35GM130289 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI Xuewu Zhang · 2019 to 2026
$3.6MIntegrative Analysis to Identify Therapeutic Targets for Lung CancerR01CA172211 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI XIAO, GUANGHUA · 2013 to 2017
$1.6MIntegrative Analysis to Identify Regulation Targets of RNA-Binding ProteinsR01GM115473 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI XIE, YANG · 2016 to 2019
$1.3MBiotechnology and Biological Sciences Research Council BBS/E/B/000C0413Medical Research CouncilNCI NIH HHS R01 CA172211NIAID NIH HHS U19 AI109725NIAID NIH HHS U19 AI142784NIDDK NIH HHS P30 DK043351NIDDK NIH HHS R01 DK097485NIGMS NIH HHS R01 GM115473NIGMS NIH HHS R35 GM130289Wellcome Trust 104568/Z/14/2
Abstract
Autophagy, a process of degradation that occurs via the lysosomal pathway, has an essential role in multiple aspects of immunity, including immune system development, regulation of innate and adaptive immune and inflammatory responses, selective degradation of intracellular microorganisms, and host protection against infectious diseases
Indexed as
AnimalsAutophagyAutophagy-Related ProteinsBeclin-1Cell LineClass III Phosphatidylinositol 3-KinasesEndosomesFemaleHumansIn Vitro TechniquesMaleMiceMice, Inbred C57BLRNA, Small InterferingSorting NexinsVesicular Transport ProteinsAtg14 protein, mouseAutophagy-Related ProteinsBeclin-1Class III Phosphatidylinositol 3-KinasesRNA, Small InterferingSNX5 protein, humanSnx5 protein, mouseSorting NexinsVesicular Transport Proteins
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.