Evidence map›Paper›PMID 33328635›Full record

ArticleNature2021

Cortical response selectivity derives from strength in numbers of synapses.

Benjamin Scholl, Connon I Thomas, Melissa A Ryan, Naomi Kamasawa, David Fitzpatrick

Erratum issuedAbstract read
In one paragraph

Article in Nature, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 52 papers.

0numbers the graph read from it
0cells of the map it votes in
52citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

52 citing papers in PubMed.

  1. Article
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  14. H-Ras induces exuberantiScience · 2024
    Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Heterosynaptic plasticity-induced modulation of synapses.The journal of physiological sciences : JPS · 2023
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Benjamin Scholl *Functional Architecture and Development of Cerebral Cortex, Max Planck Florida Institute for Neuroscience, Jupiter, FL, USA. scholl.ben@gmail.com.ORCID http://orcid.org/0000-0002-9578-7234
Connon I Thomas *Electron Microscopy Core Facility, Max Planck Florida Institute for Neuroscience, Jupiter, FL, USA.ORCID http://orcid.org/0000-0003-0995-9667
Melissa A RyanElectron Microscopy Core Facility, Max Planck Florida Institute for Neuroscience, Jupiter, FL, USA.
Naomi KamasawaElectron Microscopy Core Facility, Max Planck Florida Institute for Neuroscience, Jupiter, FL, USA.
David FitzpatrickFunctional Architecture and Development of Cerebral Cortex, Max Planck Florida Institute for Neuroscience, Jupiter, FL, USA.ORCID http://orcid.org/0000-0001-6955-0252

Funding

The Development of Direction Selectivity in Visual CortexR01EY011488 · NEI · MAX PLANCK FLORIDA CORPORATION · PI FITZPATRICK, DAVID · 1996 to 2025
$10.6M
Functional Synaptic Architecture of Visual CortexR01EY006821 · NEI · MAX PLANCK FLORIDA CORPORATION · PI FITZPATRICK, DAVID · 1987 to 2020
$7.2M
Principles of presynaptic networks for single layer 2/3 neurons in ferret visual cortexK99EY031137 · NEI · MAX PLANCK FLORIDA CORPORATION · PI SCHOLL, BENJAMIN KYLE · 2020 to 2021
$216k
NEI NIH HHS K99 EY031137NEI NIH HHS R01 EY011488
6 · The paper itself

Abstract

Single neocortical neurons are driven by populations of excitatory inputs, which form the basis of neuronal selectivity to features of sensory input. Excitatory connections are thought to mature during development through activity-dependent Hebbian plasticity

Indexed as

Neural PathwaysAnimalsFemaleFerretsMicroscopy, Electron, ScanningModels, NeurologicalPhotic StimulationPyramidal CellsSynapsesVisual Cortex

Identifiers

PMID33328635
PMCPMC7872059

What OpenQuestion holds

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LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.