Evidence map›Paper›PMID 33328630›Full record

ArticleNature2021

Reconstitution of the oocyte transcriptional network with transcription factors.

Nobuhiko Hamazaki, Hirohisa Kyogoku, Hiromitsu Araki, Fumihito Miura, Chisako Horikawa, Norio Hamada, So Shimamoto, Orie Hikabe, Kinichi Nakashima, Tomoya S Kitajima and 3 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 86 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
86citing papers in PubMed, 1 pooled it
16.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

86 citing papers in PubMed, 1 synthesis or guideline pooled it, 140 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Deletion of Ybx1 results in germ cell hypoplasia in mouse embryos.The Journal of reproduction and development · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. What a (re)productive year it has been!Journal of assisted reproduction and genetics · 2026
    Article
  13. Article
  14. The intrinsic impact of mechanical stress on the maintenance of oocyte dormancy.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Article

26 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 2 countries.

Nobuhiko HamazakiDepartment of Stem Cell Biology and Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan. hamazaki@hgs.med.kyushu-u.ac.jp.ORCID http://orcid.org/0000-0001-9228-233X
Hirohisa KyogokuLaboratory for Chromosome Segregation, RIKEN Center for Biosystems Dynamics Research, Kobe, Japan.
Hiromitsu ArakiDepartment of Biochemistry, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Fumihito MiuraDepartment of Biochemistry, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.ORCID http://orcid.org/0000-0003-2656-486X
Chisako HorikawaDepartment of Stem Cell Biology and Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Norio HamadaDepartment of Stem Cell Biology and Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
So ShimamotoDepartment of Stem Cell Biology and Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Orie HikabeDepartment of Stem Cell Biology and Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Kinichi NakashimaDepartment of Stem Cell Biology and Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.ORCID http://orcid.org/0000-0001-5901-9628
Tomoya S KitajimaLaboratory for Chromosome Segregation, RIKEN Center for Biosystems Dynamics Research, Kobe, Japan.ORCID http://orcid.org/0000-0002-6486-7143
Takashi ItoDepartment of Biochemistry, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.ORCID http://orcid.org/0000-0001-6097-2803
Harry G LeitchMRC London Institute of Medical Sciences (LMS), London, UK.ORCID http://orcid.org/0000-0002-3486-8962
Katsuhiko HayashiDepartment of Stem Cell Biology and Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan. hayashik@hgs.med.kyushu-u.ac.jp.ORCID http://orcid.org/0000-0002-2479-2941
Kyushu University · JPRIKEN Center for Biosystems Dynamics Research · JPMRC London Institute of Medical Sciences · GB

Funding

Medical Research Council MC_UP_1605/2
6 · The paper itself

Abstract

During female germline development, oocytes become a highly specialized cell type and form a maternal cytoplasmic store of crucial factors. Oocyte growth is triggered at the transition from primordial to primary follicle and is accompanied by dynamic changes in gene expression

Indexed as

AnimalsCell LineageEpigenesis, GeneticFemaleFertilizationMeiosisMethylationMiceOocytesOogenesisOvarian FolliclePluripotent Stem CellsTranscription FactorsTranscription Factors

Identifiers

PMID33328630
OpenAlexW3111038068

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.