Evidence map›Paper›PMID 33328477›Full record

ArticleNature communications2020

Eosinophils improve cardiac function after myocardial infarction.

Jing Liu, Chongzhe Yang, Tianxiao Liu, Zhiyong Deng, Wenqian Fang, Xian Zhang, Jie Li, Qin Huang, Conglin Liu, Yunzhe Wang and 13 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 89 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
89citing papers in PubMed, 2 pooled it
10.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

89 citing papers in PubMed, 2 syntheses or guidelines pooled it, 122 citations in OpenAlex.

  1. Myocardial Immune Cells: The Basis of Cardiac Immunology.Journal of immunology (Baltimore, Md. : 1950) · 2023
    Pooled it
  2. Pooled it
  3. Trial
  4. Trial
  5. Review
  6. Article
  7. Review
  8. Tissue adaptation of eosinophils.Journal of leukocyte biology · 2026
    Review
  9. Review
  10. Article
  11. The Potential of the Gut Microbiota and Butyrate to Enhance CAR T-cell Therapy in Non-Hodgkin Lymphoma.Clinical cancer research : an official journal of the American Association for Cancer Research · 2026
    Article
  12. Review
  13. Article
  14. Review
  15. Review
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article

29 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

23 authors at 5 institutions in 3 countries.

Jing LiuDepartment of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 02115, USA.
Chongzhe YangDepartment of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 02115, USA.
Tianxiao LiuDepartment of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 02115, USA.
Zhiyong DengDepartment of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 02115, USA.
Wenqian FangDepartment of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 02115, USA.
Xian ZhangDepartment of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 02115, USA.
Jie LiDepartment of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 02115, USA.
Qin HuangDepartment of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 02115, USA.
Conglin LiuDepartment of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 02115, USA.
Yunzhe WangDepartment of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 02115, USA.
Dafeng YangDepartment of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 02115, USA.
Galina K SukhovaDepartment of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 02115, USA.
Jes S LindholtDepartment of Cardiothoracic and Vascular Surgery, Odense University Hospital, Odense, Denmark.
Axel DiederichsenElitary Research Centre of personalised medicine in arterial disease (CIMA), Odense University Hospital, Odense, Denmark.ORCID 0000-0002-1285-4826
Lars M RasmussenElitary Research Centre of personalised medicine in arterial disease (CIMA), Odense University Hospital, Odense, Denmark.
Dazhu LiLaboratory of Cardiovascular Immunology, Institute of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Gail NewtonDepartment of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 02115, USA.
Francis W LuscinskasDepartment of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 02115, USA.
Lijun LiuDepartment of Biochemistry and Cancer Biology, College of Medicine and Life Sciences, University of Toledo, Toledo, OH, 43614, USA.
Peter LibbyDepartment of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 02115, USA.ORCID 0000-0002-1502-502X
Jing WangState Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Department of Pathophysiology, Peking Union Medical College, Beijing, 100005, China. wangjing@ibms.pumc.edu.cn.ORCID 0000-0003-2410-5408
Junli GuoDepartment of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 02115, USA. guojl0511@126.com.ORCID 0000-0002-9740-9819
Guo-Ping ShiDepartment of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 02115, USA. gshi@bwh.harvard.edu.ORCID 0000-0001-5809-2567
Brigham and Women's Hospital · USOdense University Hospital · DKChinese Academy of Medical Sciences & Peking Union Medical College · CNUnion Hospital · CNUniversity of Toledo · US

Funding

Role of mast cells in obesityR01HL060942 · NHLBI · UNIVERSITY OF CALIFORNIA SAN FRANCISCO · PI SHI, GUO-PING · 1999 to 2019
$5.6M
Molecular Determinants of Arterial Remodeling in AtherogenesisR01HL080472 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI LIBBY, PETER · 2005 to 2018
$5.0M
Role of Mast cells in Alzheimer's DiseaseR01AG063839 · NIA · BRIGHAM AND WOMEN'S HOSPITAL · PI LIBBY, PETER · 2020 to 2024
$3.1M
Role of a novel IL18 binding protein in atherosclerosisR01HL123568 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI SHI, GUO-PING · 2015 to 2018
$1.7M
Role of mast cells in Alzheimer's DiseaseR56AG058670 · NIA · BRIGHAM AND WOMEN'S HOSPITAL · PI SHI, GUO-PING · 2018 to 2018
$415k
NHLBI NIH HHS R01 HL060942NHLBI NIH HHS R01 HL080472NHLBI NIH HHS R01 HL123568NIA NIH HHS R01 AG063839NIA NIH HHS R56 AG058670
6 · The paper itself

Abstract

Clinical studies reveal changes in blood eosinophil counts and eosinophil cationic proteins that may serve as risk factors for human coronary heart diseases. Here we report an increase of blood or heart eosinophil counts in humans and mice after myocardial infarction (MI), mostly in the infarct region. Genetic or inducible depletion of eosinophils exacerbates cardiac dysfunction, cell death, and fibrosis post-MI, with concurrent acute increase of heart and chronic increase of splenic neutrophils and monocytes. Mechanistic studies reveal roles of eosinophil IL4 and cationic protein mEar1 in blocking H

Indexed as

AgedAnimalsCell DeathDiphtheria ToxinElectrocardiographyEosinophilsFemaleFibroblastsHumansInterleukin-4MaleMice, Inbred BALB CMice, Inbred C57BLMice, TransgenicMyocardial InfarctionMyocardiumDiphtheria ToxinEar1 protein, mouseIl4 protein, mouseInterleukin-4Ribonucleases

Identifiers

PMID33328477
PMCPMC7745020
OpenAlexW3112149209

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.