ArticleNature communications2020
FUT2-ABO epistasis increases the risk of early childhood asthma and Streptococcus pneumoniae respiratory illnesses.
Open access · goldAbstract read
In one paragraph
Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 2 pooled it
3.4field-weighted citation impact, top 7% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 48 citations in OpenAlex.
- Genetic characterization of preschool wheeze phenotypes.The Journal of allergy and clinical immunology · 2025Pooled it
- Pooled it
- Duration and severity of asthma-like episodes in young children vary by viral and bacterial triggers.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2026Article
- Fucosyltransferases in asthma: regulators of epithelial dysfunction, senescence, and airway inflammation.Clinical reviews in allergy & immunology · 2026Review
- Why Are Some Children More Sick Than Others? Lessons From Genome-wide Association Studies of Respiratory Viral Infections.The Pediatric infectious disease journal · 2026Article
- Isohemagglutinins exhibit synergistic polyreactivity toward Streptococcus pneumoniae surface antigens: implications for broad-spectrum reactivity of human antibodies.Medical microbiology and immunology · 2026Article
- Interactions with polygenic background impact quantitative traits in the UK Biobank.medRxiv : the preprint server for health sciences · 2025Article
- The role of theERJ open research · 2025Article
- Vitamin D-FUT2 interaction and risk of lower respiratory tract infections in childhood.Allergy · 2025Article
- Impact of Early-Life Microbiota on Immune System Development and Allergic Disorders.Biomedicines · 2025Review
- Noninvasive assessment of organ-specific and shared pathways in multi-organ fibrosis using T1 mapping.Nature medicine · 2024Article
- The Exploitation of the Glycosylation Pattern in Asthma: How We Alter Ancestral Pathways to Develop New Treatments.Biomolecules · 2024Review
- Link between respiratory microbiota and asthma: an emerging therapeutic approach.American journal of translational research · 2024Review
- Incidence rates of childhood asthma with recurrent exacerbations in the US Environmental influences on Child Health Outcomes (ECHO) program.The Journal of allergy and clinical immunology · 2023Article
- Will This Toddler Wheeze Again?The journal of allergy and clinical immunology. In practice · 2023Article
- Asthma Exacerbations: The Genes Behind the Scenes.Journal of investigational allergology & clinical immunology · 2023Review
- Review
- Winds of change a tale of: asthma and microbiome.Frontiers in microbiology · 2023Review
- ABO, secretor, and Lewis carbohydrate histo-blood groups are associated with autoimmune neutropenia of early childhood in Danish patients.Transfusion · 2022Article
- A whole genome sequencing study of moderate to severe asthma identifies a lung function locus associated with asthma risk.Scientific reports · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
33 authors at 10 institutions in 2 countries.
Tarunveer S AhluwaliaCOPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0002-7464-3354
Anders U EliasenCOPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.
Astrid SevelstedCOPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0001-7117-2334
Casper-Emil T PedersenCOPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0003-2540-5373
Jakob StokholmCOPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0003-4989-9769
Bo ChawesCOPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0001-6846-6243
Jette Bork-JensenNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Niels GrarupNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0001-5526-1070
Oluf PedersenNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0002-3321-3972
Torben HansenNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0001-8748-3831
Allan LinnebergCenter for Clinical Research and Disease Prevention, Bispebjerg and Frederiksberg Hospital, The Capital Region, Copenhagen, Denmark.ORCID 0000-0002-0994-0184
Amitabh SharmaChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Scott T WeissChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.ORCID 0000-0001-7196-303X
Michael D EvansClinical and Translational Science Institute, University of Minnesota, Minneapolis, MN, USA.ORCID 0000-0001-7449-3993
Daniel J JacksonDepartment of Pediatrics, University of Wisconsin, Madison, WI, USA.
Andreanne MorinDepartment of Human Genetics, University of Chicago, Chicago, IL, USA.ORCID 0000-0002-5535-9518
Karen A KrogfeltDepartment of Bacteria, Parasites and Fungi, Statens Serum Institut, Copenhagen, Denmark.ORCID 0000-0001-7536-3453
Susanne SchjørringDepartment of Bacteria, Parasites and Fungi, Statens Serum Institut, Copenhagen, Denmark.ORCID 0000-0001-5575-7252
Preben B MortenseniPSYCH, The Lundbeck Foundation Initiative for Integrated Psychiatric Research, Copenhagen, Denmark.
David M HougaardiPSYCH, The Lundbeck Foundation Initiative for Integrated Psychiatric Research, Copenhagen, Denmark.ORCID 0000-0001-5928-3517
Jonas Bybjerg-GrauholmiPSYCH, The Lundbeck Foundation Initiative for Integrated Psychiatric Research, Copenhagen, Denmark.ORCID 0000-0003-1705-4008
Marie Bækvad-HanseniPSYCH, The Lundbeck Foundation Initiative for Integrated Psychiatric Research, Copenhagen, Denmark.
Ole MorsiPSYCH, The Lundbeck Foundation Initiative for Integrated Psychiatric Research, Copenhagen, Denmark.
Merete NordentoftiPSYCH, The Lundbeck Foundation Initiative for Integrated Psychiatric Research, Copenhagen, Denmark.
Anders D BørglumiPSYCH, The Lundbeck Foundation Initiative for Integrated Psychiatric Research, Copenhagen, Denmark.ORCID 0000-0001-8627-7219
Thomas WergeiPSYCH, The Lundbeck Foundation Initiative for Integrated Psychiatric Research, Copenhagen, Denmark.ORCID 0000-0003-1829-0766
Esben AgerboiPSYCH, The Lundbeck Foundation Initiative for Integrated Psychiatric Research, Copenhagen, Denmark.ORCID 0000-0002-2849-524X
James E GernDepartment of Pediatrics, University of Wisconsin, Madison, WI, USA.ORCID 0000-0002-6667-4708
Robert F LemanskeDepartment of Pediatrics, University of Wisconsin, Madison, WI, USA.
Carole OberDepartment of Human Genetics, University of Chicago, Chicago, IL, USA.
Anders G PedersenSection for Bioinformatics, Department of Health Technology, Technical University of Denmark, Copenhagen, Denmark.ORCID 0000-0001-9650-8965
Hans BisgaardCOPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0003-4131-7592
Klaus BønnelykkeCOPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark. kb@copsac.com.ORCID 0000-0003-2003-1018
University of Copenhagen · DKStatens Serum Institut · DKAarhus University · DKUniversity of Wisconsin–Madison · USBrigham and Women's Hospital · USUniversity of Chicago · USAarhus University Hospital · DKCopenhagen University Hospital · DKTechnical University of Denmark · DKUniversity of Minnesota · US
Funding
Prenatal Origins of AsthmaR01HL129735 · NHLBI · UNIVERSITY OF CHICAGO · PI BISGAARD, HANS, OBER, CAROLE · 2015 to 2018
$3.2MNHLBI NIH HHS R01 HL129735
Abstract
Asthma with severe exacerbation is the most common cause of hospitalization among young children. We aim to increase the understanding of this clinically important disease entity through a genome-wide association study. The discovery analysis comprises 2866 children experiencing severe asthma exacerbation between ages 2 and 6 years, and 65,415 non-asthmatic controls, and we replicate findings in 918 children from the Copenhagen Prospective Studies on Asthma in Childhood (COPSAC) birth cohorts. We identify rs281379 near FUT2/MAMSTR on chromosome 19 as a novel risk locus (OR = 1.18 (95% CI = 1.11-1.25), P
Indexed as
Epistasis, GeneticABO Blood-Group SystemAsthmaCase-Control StudiesChildChild, PreschoolFemaleFucosyltransferasesGalactoside 2-alpha-L-fucosyltransferaseGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansMalePneumococcal InfectionsPolymorphism, Single NucleotideStreptococcus pneumoniaeABO Blood-Group SystemFucosyltransferasesGalactoside 2-alpha-L-fucosyltransferase
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.