Evidence map›Paper›PMID 33328352›Full record

ArticlemSphere2020

Suppressor Mutations in Type II Secretion Mutants of Vibrio cholerae: Inactivation of the VesC Protease.

Chelsea S Rule, Young-Jun Park, Jaclyn R Delarosa, Stewart Turley, Wim G J Hol, Sarah McColm, Colby Gura, Frank DiMaio, Konstantin V Korotkov, Maria Sandkvist

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mSphere, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Chelsea S RuleDepartment of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan, USA.
Young-Jun ParkDepartment of Biochemistry, University of Washington, Seattle, Washington, USA.
Jaclyn R DelarosaDepartment of Biochemistry, University of Washington, Seattle, Washington, USA.
Stewart TurleyDepartment of Biochemistry, University of Washington, Seattle, Washington, USA.
Wim G J HolDepartment of Biochemistry, University of Washington, Seattle, Washington, USA.
Sarah McColmDepartment of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan, USA.
Colby GuraDepartment of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan, USA.
Frank DiMaioDepartment of Biochemistry, University of Washington, Seattle, Washington, USA.
Konstantin V KorotkovDepartment of Biochemistry, University of Washington, Seattle, Washington, USA.ORCID 0000-0002-2182-6843
Maria SandkvistDepartment of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan, USA mariasan@umich.edu.
University of Washington · USUniversity of Michigan · USUniversity of Kentucky · US

Funding

X-ray Absorption Spectroscopy (XAS) pp.711-759P41GM103393 · NIGMS · STANFORD UNIVERSITY · PI HODGSON, KEITH O · 2012 to 2019
$30.6M
STRUCTURAL STUDY OF HEAT-LABILE ENTEROTOXINR01AI034501 · NIAID · UNIVERSITY OF WASHINGTON · PI HOL, WILHELMUS G. J. · 1993 to 2013
$5.4M
Organization and Function of a Type II Secretion ComplexR01AI049294 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SANDKVIST, MARIA B · 2002 to 2012
$2.9M
Protein structure determination from low-resolution experimental dataR01GM123089 · NIGMS · UNIVERSITY OF WASHINGTON · PI DIMAIO, FRANK P · 2017 to 2025
$2.6M
Molecular Mechanisms of Protein Sorting by the Type II Secretion SystemR01AI137085 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SANDKVIST, MARIA B · 2018 to 2022
$2.0M
NIAID NIH HHS R01 AI034501NIAID NIH HHS R01 AI049294NIAID NIH HHS R01 AI137085NIGMS NIH HHS P41 GM103393NIGMS NIH HHS R01 GM123089
6 · The paper itself

Abstract

The type II secretion system (T2SS) is a conserved transport pathway responsible for the secretion of a range of virulence factors by many pathogens, including

Indexed as

Amino Acid SequenceBacterial ProteinsCrystallography, X-RayMembrane ProteinsMutagenesisMutationPeptide HydrolasesSuppression, GeneticVibrioVibrio choleraeBacterial ProteinsMembrane ProteinsPeptide Hydrolasesprotein structureserine proteasesuppressortype II secretion systemVibrio cholerae

Identifiers

PMID33328352
PMCPMC7771236
OpenAlexW3110948615

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.