ArticlePediatrics2021
Development of a Quality Improvement Learning Collaborative to Improve Pediatric Sepsis Outcomes.
Article in Pediatrics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 61 citations in OpenAlex.
- Early recognition and bundle-based management of pediatric sepsis in the emergency department: a narrative review.Translational pediatrics · 2026Review
- Care Pathway and Outcomes in Pediatric Septic Shock: A Narrative Review from Emergency Department Recognition to PICU Management.Children (Basel, Switzerland) · 2026Review
- To: Improving the outcomes of sepsis in Brazil: strategies and initiatives.Critical care science · 2026Article
- Triage Temperature and Timeliness of Sepsis Interventions in a Pediatric Emergency Department.The western journal of emergency medicine · 2025Article
- Human performance evaluation of a pediatric artificial intelligence sepsis model.Journal of the American Medical Informatics Association : JAMIA · 2025Article
- Early clinical evaluation of a vendor developed pediatric artificial intelligence sepsis model in the emergency department.Journal of the American Medical Informatics Association : JAMIA · 2025Article
- Prolonged Inotrope Use After Surgery for Congenital Heart Disease: A Common Occurrence with a High Burden of Mortality.Pediatric cardiology · 2025Article
- Predicting sepsis treatment decisions in the paediatric emergency department using machine learning: the AiSEPTRON study.BMJ paediatrics open · 2025Observational
- Epinephrine vs Norepinephrine as Initial Treatment in Children With Septic Shock.JAMA network open · 2025Article
- Delays to Antibiotics in the Emergency Department and Risk of Mortality in Children With Sepsis.JAMA network open · 2024Article
- Identifying the capabilities for creating next-generation registries: a guide for data leaders and a case for "registry science".Journal of the American Medical Informatics Association : JAMIA · 2024Article
- Sociodemographic Factors are Associated with Care Delivery and Outcomes in Pediatric Severe Sepsis.Critical care explorations · 2024Article
- Implementation of a Virtual Interprofessional ICU Learning Collaborative: Successes, Challenges, and Initial Reactions From the Structured Team-Based Optimal Patient-Centered Care for Virus COVID-19 Collaborators.Critical care explorations · 2023Article
- Less is more: Antibiotics at the beginning of life.Nature communications · 2023Review
- Screening for Social Determinants of Health in the Pediatric Intensive Care Unit: Recommendations for Clinicians.Critical care clinics · 2023Review
- Implementing Pediatric Surviving Sepsis Campaign Guidelines: Improving Compliance With Lactate Measurement in the PICU.Critical care explorations · 2023Article
- Article
- Antibiotic treatment duration for culture-negative sepsis in the pediatric intensive care unit.Antimicrobial stewardship & healthcare epidemiology : ASHE · 2023Article
- Identification of sepsis in paediatric emergency departments: A scoping review.Acta paediatrica (Oslo, Norway : 1992) · 2022Article
- "These Are Our Kids": Qualitative Interviews With Clinical Leaders in General Emergency Departments on Motivations, Processes, and Guidelines in Pediatric Sepsis Care.Annals of emergency medicine · 2022Article
Corrections and comments
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Authors and funding
25 authors at 18 institutions in 1 country.
Funding
Abstract
Pediatric sepsis is a major public health problem. Published treatment guidelines and several initiatives have increased adherence with guideline recommendations and have improved patient outcomes, but the gains are modest, and persistent gaps remain. The Children's Hospital Association Improving Pediatric Sepsis Outcomes (IPSO) collaborative seeks to improve sepsis outcomes in pediatric emergency departments, ICUs, general care units, and hematology/oncology units. We developed a multicenter quality improvement learning collaborative of US children's hospitals. We reviewed treatment guidelines and literature through 2 in-person meetings and multiple conference calls. We defined and analyzed baseline sepsis-attributable mortality and hospital-onset sepsis and developed a key driver diagram (KDD) on the basis of treatment guidelines, available evidence, and expert opinion. Fifty-six hospital-based teams are participating in IPSO; 100% of teams are engaged in educational and information-sharing activities. A baseline, sepsis-attributable mortality of 3.1% was determined, and the incidence of hospital-onset sepsis was 1.3 cases per 1000 hospital admissions. A KDD was developed with the aim of reducing both the sepsis-attributable mortality and the incidence of hospital-onset sepsis in children by 25% from baseline by December 2020. To accomplish these aims, the KDD primary drivers focus on improving the following: treatment of infection; recognition, diagnosis, and treatment of sepsis; de-escalation of unnecessary care; engagement of patients and families; and methods to optimize performance. IPSO aims to improve sepsis outcomes through collaborative learning and reliable implementation of evidence-based interventions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.