Evidence map›Paper›PMID 33328302›Full record

ArticleJournal of virology2021

Membrane-associated and secreted forms of the Rhesus macaque rhadinovirus-encoded CD200 homologue and cellular CD200 demonstrate differential effects on Rhesus Macaque CD200 Receptor signaling and regulation of myeloid cell activation.

Ryan D Estep, Aparna N Govindan, Kristin Fitzpatrick, Tiffany C Blair, S A Rahim Rezaee, David J Blackbourn, Scott W Wong

Open access · greenAbstract read
In one paragraph

Article in Journal of virology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 84% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 3 countries.

Ryan D EstepVaccine and Gene Therapy Institute, Oregon Health & Science University, Beaverton, OR, United States of America wongs@ohsu.edu estepr@ohsu.edu.
Aparna N GovindanVaccine and Gene Therapy Institute, Oregon Health & Science University, Beaverton, OR, United States of America.
Kristin FitzpatrickVaccine and Gene Therapy Institute, Oregon Health & Science University, Beaverton, OR, United States of America.
Tiffany C BlairVaccine and Gene Therapy Institute, Oregon Health & Science University, Beaverton, OR, United States of America.
S A Rahim RezaeeImmunology Research center, Immunology Department Ghaem Hospital, Medical School, Mashhad University of Medical Sciences, Mashhad, Iran.ORCID https://orcid.org/0000-0001-6814-5992
David J BlackbournSchool of Biosciences and Medicine, University of Surrey, Guildford, UK.
Scott W WongVaccine and Gene Therapy Institute, Oregon Health & Science University, Beaverton, OR, United States of America wongs@ohsu.edu estepr@ohsu.edu.
Children's Cancer Therapy Development Institute · USMashhad University of Medical Sciences · IROregon National Primate Research Center · USUniversity of Surrey · GB

Funding

Upgrade of confocal microscopy at the Oregon National Primate Research CenterP51OD011092 · OD · OREGON HEALTH & SCIENCE UNIVERSITY · PI Bonnie J. Nagel · 2012 to 2026
$203.9M
RHESUS HHV 8 HOMOLOGUE IN AIDS RELATED MALIGNANCIESR01CA075922 · NCI · OREGON REGIONAL PRIMATE RESEARCH CENTER · PI WONG, SCOTT W · 1997 to 2024
$16.7M
Investigating the development of AIDs and non-AIDS defining cancers in aged SIV-infected rhesus macaques.R01CA206404 · NCI · OREGON HEALTH & SCIENCE UNIVERSITY · PI WONG, SCOTT W · 2016 to 2020
$5.7M
NCI NIH HHS R01 CA075922NCI NIH HHS R01 CA206404NIH HHS P51 OD011092
6 · The paper itself

Abstract

The CD200-CD200R pathway is involved in inhibition of immune responses, and the importance of this pathway to infectious disease is highlighted by the fact that viral CD200 (vCD200) molecules have been found to be encoded by several DNA viruses, including the human gammaherpesvirus Kaposi's sarcoma-associated herpesvirus (KSHV), and the closely related rhesus macaque rhadinovirus (RRV). KSHV vCD200 is the most extensively studied vCD200 molecule, however, the only herpesvirus vCD200 molecule to be examined

Identifiers

PMID33328302
PMCPMC8092840
OpenAlexW3112527896

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.