ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2021
Aberrant Maturation of the Uncinate Fasciculus Follows Exposure to Unpredictable Patterns of Maternal Signals.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
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Who cites it
49 citing papers in PubMed, 62 citations in OpenAlex.
- Exploring the impact of unpredictability of household resources on infant attention.Infant behavior & development · 2026Article
- Early life stress induces sex-specific changes in cognitive and affective behavior associated with disrupted noradrenergic physiology.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Developmental origins of ADHD: sex-specific influences of early life unpredictability on symptom profiles.Journal of developmental origins of health and disease · 2026Article
- A Comprehensive Characterization of the Phospholipid and Cholesterol Composition of the Uncinate Fasciculus in the Human Brain: Evidence of Age-Related Alterations.Journal of neurochemistry · 2026Article
- Unpredictable maternal signals and developmental profiles of child executive function from infancy to early childhood.Developmental cognitive neuroscience · 2026Article
- Maternal mood entropy and children's hippocampal development: Enduring versus transient effects.Development and psychopathology · 2026Article
- Evaluating oxidative stress marker FBMC pediatrics · 2026Article
- Anhedonia underlies the association between childhood unpredictability and adult PTSD symptoms: Evidence from three independent longitudinal cohorts.Psychological medicine · 2026Article
- Practical judgment in aging: examining behavioral vulnerabilities and neurobiological correlates.Frontiers in psychology · 2026Article
- Unpredictability is a childhood adversity that contributes to mental health problems.Nature. Mental health · 2026Article
- Prenatal maternal mood instability and child externalizing problems: An ecological momentary assessment study.Journal of affective disorders · 2025Article
- Sex-Specific Effects of Early-Life Unpredictability on Hippocampal and Amygdala Responses to Novelty in Adolescents.Biological psychiatry global open science · 2025Article
- Exposure to unpredictable childhood environments is associated with amygdala activation during early extinction in adulthood.Developmental cognitive neuroscience · 2025Article
- Aberrant neural event segmentation during a continuous social narrative in trauma-exposed older adolescents and young adults.Cognitive, affective & behavioral neuroscience · 2025Article
- The evolving neurobiology of early-life stress.Neuron · 2025Review
- Associations of interpersonal and socioeconomic early life adversity dimensions with adolescents' corticolimbic circuits, cognition, and mental health.Translational psychiatry · 2025Article
- Instability in the environment and children's in-school self-regulatory behaviors.Frontiers in psychology · 2025Article
- Functional Neurologic Disorder,Neurology · 2024Article
- Association between prenatal maternal sleep quality, neonatal uncinate fasciculus white matter, and infant negative emotionality.EBioMedicine · 2024Article
- Leveraging the science of early life predictability to inform policies promoting child health.Developmental cognitive neuroscience · 2024Review
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
Across species, unpredictable patterns of maternal behavior are emerging as novel predictors of aberrant cognitive and emotional outcomes later in life. In animal models, exposure to unpredictable patterns of maternal behavior alters brain circuit maturation and cognitive and emotional outcomes. However, whether exposure to such signals in humans alters the development of brain pathways is unknown. In mother-child dyads, we tested the hypothesis that exposure to more unpredictable maternal signals in infancy is associated with aberrant maturation of corticolimbic pathways. We focused on the uncinate fasciculus, the primary fiber bundle connecting the amygdala to the orbitofrontal cortex and a key component of the medial temporal lobe-prefrontal cortex circuit. Infant exposure to unpredictable maternal sensory signals was assessed at 6 and 12 months. Using high angular resolution diffusion imaging, we quantified the integrity of the uncinate fasciculus using generalized fractional anisotropy (GFA). Higher maternal unpredictability during infancy presaged greater uncinate fasciculus GFA in children 9-11 years of age (
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.