Evidence map›Paper›PMID 33328292›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2021

Basal Ganglia Output Has a Permissive Non-Driving Role in a Signaled Locomotor Action Mediated by the Midbrain.

Sebastian Hormigo, Ji Zhou, Dorian Chabbert, Bharanidharan Shanmugasundaram, Manuel A Castro-Alamancos

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.4field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. Article
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  5. Article
  6. Article
  7. Review
  8. The Orienting Reflex Reveals Behavioral States Set by Demanding Contexts: Role of the Superior Colliculus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023
    Article
  9. Caution Influences Avoidance and Approach Behaviors Differently.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022
    Article
  10. A Signaled Locomotor Avoidance Action Is Fully Represented in the Neural Activity of the Midbrain Tegmentum.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021
    Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Sebastian HormigoDepartment of Neuroscience, University of Connecticut School of Medicine, Farmington, Connecticut 06001.ORCID 0000-0003-3141-5965
Ji ZhouDepartment of Neuroscience, University of Connecticut School of Medicine, Farmington, Connecticut 06001.
Dorian ChabbertDepartment of Neuroscience, University of Connecticut School of Medicine, Farmington, Connecticut 06001.
Bharanidharan ShanmugasundaramDepartment of Neuroscience, University of Connecticut School of Medicine, Farmington, Connecticut 06001.
Manuel A Castro-AlamancosDepartment of Neuroscience, University of Connecticut School of Medicine, Farmington, Connecticut 06001 mcastro@uchc.edu.ORCID 0000-0002-2916-9585
University of Connecticut · US

Funding

Sensory pathways for stimulus detection during behaviorR35NS097272 · NINDS · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI CASTRO-ALAMANCOS, MANUEL A · 2017 to 2024
$4.3M
Neural mechanisms of active avoidance behaviorR01NS104810 · NINDS · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI CASTRO-ALAMANCOS, MANUEL A · 2018 to 2022
$2.8M
NINDS NIH HHS R01 NS104810NINDS NIH HHS R35 NS097272
6 · The paper itself

Abstract

The basal ganglia are important for movement and reinforcement learning. Using mice of either sex, we found that the main basal ganglia GABAergic output in the midbrain, the substantia nigra pars reticulata (SNr), shows movement-related neural activity during the expression of a negatively reinforced signaled locomotor action known as signaled active avoidance; this action involves mice moving away during a warning signal to avoid a threat. In particular, many SNr neurons deactivate during active avoidance responses. However, whether SNr deactivation has an essential role driving or regulating active avoidance responses is unknown. We found that optogenetic excitation of SNr or striatal GABAergic fibers that project to an area in the pedunculopontine tegmentum (PPT) within the midbrain locomotor region abolishes signaled active avoidance responses, while optogenetic inhibition of SNr cells (mimicking the SNr deactivation observed during an active avoidance behavior) serves as an effective conditioned stimulus signal to drive avoidance responses by disinhibiting PPT neurons. However, preclusion of SNr deactivation, or direct inhibition of SNr fibers in the PPT, does not impair the expression of signaled active avoidance, indicating that SNr output does not drive the expression of a signaled locomotor action mediated by the midbrain. Consistent with a permissive regulatory role, SNr output provides information about the state of the ongoing action to downstream structures that mediate the action.

Indexed as

AnimalsAvoidance LearningBasal GangliaFemalegamma-Aminobutyric AcidLocomotionMaleMesencephalonMiceNerve FibersNeural PathwaysNeuronsOptogeneticsPars ReticulataPedunculopontine Tegmental Nucleusgamma-Aminobutyric Acidaccumbensavoidanceescapemovementstriatumthreat

Identifiers

PMID33328292
PMCPMC7896017
OpenAlexW3111998451

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.