ArticleScience advances2020
Lamellar cells in Pacinian and Meissner corpuscles are touch sensors.
Article in Science advances, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 61 citations in OpenAlex.
- The Lamellar Cells of Vertebrate Meissner and Pacinian Corpuscles: Development, Characterization, and Functions.Frontiers in neuroscience · 2022Pooled it
- Peripheral mechanisms of tactile sensation in fish.Current opinion in neurobiology · 2026Review
- Exploratory Immunohistochemical Mapping of Mechanosensitivity-Associated Ion Channel Proteins in Terminal Glial Cells of Human Meissner and Pacinian Corpuscles.International journal of molecular sciences · 2026Article
- Transforming static interfaces into tactile channels with steerable transdermal foci.Science advances · 2026Article
- Velocity sensitivity of mechanotransduction in the afferent terminal underlies vibration detection in the Pacinian corpuscle.Nature communications · 2026Article
- A Tangentially Sensitive Tactile Sensor Reveals the Stick-Slip Mechanism and Enhances Robotic Tactile Sensing.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Induced Proprioceptor and Low-Threshold Mechanoreceptor Neurons Derived from Human Pluripotent Stem Cells Exhibit Distinct Functional Mechanosensory Properties.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Functional evidence for early origin of tactile acuity in the vertebrate somatosensory system.Current biology : CB · 2025Article
- Anisotropic Tactile Sensors: Constructive Designs, Challenges, and Emerging Applications.Chem & bio engineering · 2025Review
- Flexible Tactile Sensing Systems: Challenges in Theoretical Research Transferring to Practical Applications.Nano-micro letters · 2025Review
- Lamellar Schwann cells in the Pacinian corpuscle potentiate vibration perception.Science advances · 2025Article
- Mechanosensitive Ion Channels: The Unending Riddle of Mechanotransduction.Bioelectricity · 2025Review
- Evaluation of the Efficacy of Focal Vibration Therapy-Novafon as an Assistive Therapeutic Tool for Children With Feeding and Swallowing Disorders.Journal of oral rehabilitation · 2025Article
- The inner core enables transient touch detection in the Pacinian corpuscle.Science advances · 2025Article
- Axonal and Glial PIEZO1 and PIEZO2 Immunoreactivity in Human Clitoral Krause's Corpuscles.International journal of molecular sciences · 2024Article
- Origin, identity, and function of terminal Schwann cells.Trends in neurosciences · 2024Review
- Triboelectric micro-flexure-sensitive fiber electronics.Nature communications · 2024Article
- Sensory Schwann cells set perceptual thresholds for touch and selectively regulate mechanical nociception.Nature communications · 2024Article
- A helping hand: roles for accessory cells in the sense of touch across species.Frontiers in cellular neuroscience · 2024Review
- Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
The skin covering the human palm and other specialized tactile organs contains a high density of mechanosensory corpuscles tuned to detect transient pressure and vibration. These corpuscles comprise a sensory afferent neuron surrounded by lamellar cells. The neuronal afferent is thought to be the mechanical sensor, whereas the function of lamellar cells is unknown. We show that lamellar cells within Meissner and Pacinian corpuscles detect tactile stimuli. We develop a preparation of bill skin from tactile-specialist ducks that permits electrophysiological recordings from lamellar cells and demonstrate that they contain mechanically gated ion channels. We show that lamellar cells from Meissner corpuscles generate mechanically evoked action potentials using R-type voltage-gated calcium channels. These findings provide the first evidence for R-type channel-dependent action potentials in non-neuronal cells and demonstrate that lamellar cells actively detect touch. We propose that Meissner and Pacinian corpuscles use neuronal and non-neuronal mechanoreception to detect mechanical signals.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.