ReviewJournal of neurodevelopmental disorders2020
Early life stress and development: potential mechanisms for adverse outcomes.
Review in Journal of neurodevelopmental disorders, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05613972 (Using Integrated Suicide and Trauma Therapy to Reduce Suicide Risk Among Adults With a History of Childhood Trauma), which is not on this map. Cited by 264 papers, 9 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Using Integrated Suicide and Trauma Therapy to Reduce Suicide Risk Among Adults With a History of Childhood Trauma
Who cites it
264 citing papers in PubMed, 9 syntheses or guidelines pooled it, 444 citations in OpenAlex.
- Prevalence and pattern of psychological symptoms in form of dental fear and anxiety in children and adolescents with traumatic dental injuries: a systematic review.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2026Pooled it
- Global research landscape, knowledge structure, and emerging trends in adverse childhood experiences and personality disorders: a bibliometric analysis.Frontiers in psychiatry · 2026Pooled it
- Long-term alterations in pain sensitivity following preterm birth: a systematic review and meta-analysis.Frontiers in pediatrics · 2026Pooled it
- Digital technologies for non-invasive stress detection, monitoring, and mitigation in children and adolescents: a scoping review.Frontiers in digital health · 2026Pooled it
- Psychosocial adversity and executive functions in children and adolescents: a systematic review of mediating and moderating influences of parenting behaviors.BMC psychiatry · 2025Pooled it
- The effects of childhood adversity: Two specific neural patterns.Neuroscience and biobehavioral reviews · 2025Pooled it
- Early life adversity and white matter microstructural organization-a systematic review.Brain imaging and behavior · 2025Pooled it
- How childhood adversity affects components of decision making.Neuroscience and biobehavioral reviews · 2025Pooled it
- Cognitive impairment and dementia-Are they linked to childhood health and socioeconomic status? A systematic review.PloS one · 2025Pooled it
- Reducing trauma-related parental stress in neurodevelopmental disorders: a randomized feasibility study.European journal of pediatrics · 2026Trial
- A clinical assessment of the therapeutic effects of Ashwagandha root extract on cognitive performance, sleep, and fatigue in children aged 6-12 years.Frontiers in nutrition · 2026Trial
- Effects of traditional culture picture book intervention on emotional regulation ability and neuropsychology of preschool children.Frontiers in public health · 2026Trial
- Trial
- War trauma and psychomotor developmental disorders in children aged 6-12 in Lubumbashi: a comparative study.European journal of psychotraumatology · 2026Article
- Associations Between Teenage Motherhood, Perinatal Cortical Maturation, and Risk of Psychopathology in Children: The Mediating Role of Pregnancy Complications.Biological psychiatry global open science · 2026Article
- Preclinical animal models of lower urinary tract dysfunction associated with metabolic syndrome.Nature reviews. Urology · 2026Review
- Immune senescence and exhaustion in breast cancer patients with a history of childhood maltreatment.Brain, behavior, & immunity - health · 2026Article
- Stress and cardiovascular disease: Testing a vigilance pathway in two contemporary theories.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2026Article
- Early adversity promotes adolescent avoidance behavior by enhancing prefrontal-amygdala communication through CRHbioRxiv : the preprint server for biology · 2026Article
- Prenatal and early life phthalate exposure and early life stress: no interactions with adolescent internalizing symptoms.Environment international · 2026Article
204 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
backgroundChronic and/or extreme stress in early life, often referred to as early adversity, childhood trauma, or early life stress, has been associated with a wide range of adverse effects on development. However, while early life stress has been linked to negative effects on a number of neural systems, the specific mechanisms through which early life stress influences development and individual differences in children's outcomes are still not well understood. MAIN TEXT: The current paper reviews the existing literature on the neurobiological effects of early life stress and their ties to children's psychological and behavioral development.
conclusionsEarly life stress has persistent and pervasive effects on prefrontal-hypothalamic-amygdala and dopaminergic circuits that are at least partially mediated by alterations in hypothalamic-pituitary-adrenal axis function. However, to date, this research has primarily utilized methods of assessment that focus solely on children's event exposures. Incorporating assessment of factors that influence children's interpretation of stressors, along with stressful events, has the potential to provide further insight into the mechanisms contributing to individual differences in neurodevelopmental effects of early life stress. This can aid in further elucidating specific mechanisms through which these neurobiological changes influence development and contribute to risk for psychopathology and health disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.