ArticleRenal failure2021
Effects of hemodialysis treatment on saliva flow rate and saliva composition during in-center maintenance dialysis: a cross-sectional study.
Article in Renal failure, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.
- Salivary changes in chronic kidney disease and in patients undergoing hemodialysis: a systematic review and meta-analysis.Journal of nephrology · 2022Pooled it
- Salivary flow measurements in a clinical setting: the Dutch consensus statement.Clinical oral investigations · 2026Article
- Salivary Flow Rate in Patients with Kidney Failure on Hemodialysis-A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2025Review
- Exploring health challenges and coping strategies in young patients undergoing maintenance hemodialysis: a qualitative study.BMC nephrology · 2025Article
- Oral Health Status in Moroccan Hemodialysis Patients.Clinical, cosmetic and investigational dentistry · 2025Article
- Independent risk factors for thirst in hemodialysis patients: female sex, sodium profiling dialysis, and xerostomia.American journal of translational research · 2025Article
- The Oral Health Condition of Patients on Hemodialysis at a Tertiary Healthcare Facility in Eastern Nepal.International journal of dentistry · 2024Article
- Review
- Xerogenic medications may contribute to decreased unstimulated salivary flow in patients with oral burning and/or gastro-esophageal reflux disease.Frontiers in dental medicine · 2023Article
- Diurnal pattern of salivary alpha-amylase and cortisol under citric acid stimulation in young adults.PeerJ · 2022Article
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo analyze changes in saliva flow rate and clinical measures from unstimulated whole saliva (UWS) among patients undergoing hemodialysis for end-stage kidney disease (ESKD).
backgroundChronic hemodialysis causes changes in blood chemistry as well as dry mouth, due to removal of excess fluids. UWS is used to examine saliva flow rate as an indicator of mouth dryness. Whether UWS can be used to measure changes in clinical variables following hemodialysis has not been explored.
designA cross-sectional quantitative study.
methodsPatients with ESKD were recruited by purposive sampling (
resultsSaliva flow rate increased significantly from T1 to T3 (Wald χ
conclusionOur findings demonstrated saliva flow rate and several saliva components were altered during hemodialysis. The total volume of saliva secretion increased following dialysis, which can reduce xerostomia. Therefore, medical personnel could provide interventions of relieving dry mouth symptoms and increasing saliva flow rate before hemodialysis treatment.
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Registered trials
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