Evidence map›Paper›PMID 33327748›Full record

ArticleArteriosclerosis, thrombosis, and vascular biology2021

CXCR4-Binding Positron Emission Tomography Tracers Link Monocyte Recruitment and Endothelial Injury in Murine Atherosclerosis.

Osamu Baba, Li-Hao Huang, Andrew Elvington, Martyna Szpakowska, Deborah Sultan, Gyu Seong Heo, Xiaohui Zhang, Hannah Luehmann, Lisa Detering, Andy Chevigne and 2 more

Abstract read
In one paragraph

Article in Arteriosclerosis, thrombosis, and vascular biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. From incidental positron emission uptake toFrontiers in cardiovascular medicine · 2026
    Review
  5. Review
  6. Review
  7. Review
  8. Review
  9. Development of a CD163-Targeted PET Radiotracer That Images Resident Macrophages in Atherosclerosis.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2024
    Article
  10. Review
  11. Injured Endothelial Cell: A Risk Factor for Pulmonary Fibrosis.International journal of molecular sciences · 2023
    Review
  12. Article
  13. Article
  14. Review
  15. Review
  16. Review
  17. Review
  18. Development of a CCR2 targetedNuclear medicine and biology
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Osamu BabaDepartment of Pathology and Immunology (O.B., L.-H.H., A.E., G.J.R.), Washington University School of Medicine, St. Louis.
Li-Hao HuangDepartment of Pathology and Immunology (O.B., L.-H.H., A.E., G.J.R.), Washington University School of Medicine, St. Louis.
Andrew ElvingtonDepartment of Pathology and Immunology (O.B., L.-H.H., A.E., G.J.R.), Washington University School of Medicine, St. Louis.
Martyna SzpakowskaDepartment of Infection and Immunity, Luxembourg Institute of Health, Esch-sur-Alzette (M.S., A.C.).
Deborah SultanDepartment of Radiology (D.S., G.S.H., X.Z., H.L., L.D., Y.L.), Washington University School of Medicine, St. Louis.
Gyu Seong HeoDepartment of Radiology (D.S., G.S.H., X.Z., H.L., L.D., Y.L.), Washington University School of Medicine, St. Louis.
Xiaohui ZhangDepartment of Radiology (D.S., G.S.H., X.Z., H.L., L.D., Y.L.), Washington University School of Medicine, St. Louis.
Hannah LuehmannDepartment of Radiology (D.S., G.S.H., X.Z., H.L., L.D., Y.L.), Washington University School of Medicine, St. Louis.
Lisa DeteringDepartment of Radiology (D.S., G.S.H., X.Z., H.L., L.D., Y.L.), Washington University School of Medicine, St. Louis.
Andy ChevigneDepartment of Infection and Immunity, Luxembourg Institute of Health, Esch-sur-Alzette (M.S., A.C.).
Yongjian LiuDepartment of Radiology (D.S., G.S.H., X.Z., H.L., L.D., Y.L.), Washington University School of Medicine, St. Louis.
Gwendalyn J RandolphDepartment of Pathology and Immunology (O.B., L.-H.H., A.E., G.J.R.), Washington University School of Medicine, St. Louis.

Funding

WU P&FP30DK020579 · NIDDK · WASHINGTON UNIVERSITY · PI James Alexander Fitzpatrick · 2013 to 2026
$27.1M
Training/DisseminationP41EB025815 · NIBIB · WASHINGTON UNIVERSITY · PI Buck E. Rogers · 2018 to 2026
$12.7M
PRINCIPLES IN CARDIVASCULAR RESEARCH TRAINING PROGRAMT32HL007081 · NHLBI · WASHINGTON UNIVERSITY · PI Abhinav Diwan, Karen Ellen Joynt Maddox · 1985 to 2026
$10.6M
Targeted Molecular Probes for Atherosclerosis Imaging and TherapyR35HL145212 · NHLBI · WASHINGTON UNIVERSITY · PI LIU, YONGJIAN · 2019 to 2025
$5.1M
Differentiation/migratory fate of monocyte-derived cellsR01AI049653 · NIAID · WASHINGTON UNIVERSITY · PI Gwendalyn J Randolph · 2000 to 2026
$4.6M
DIFFERENTIATION AND FUNCTION OF MONOCYTES AND MACROPHAGESR37AI049653 · NIAID · WASHINGTON UNIVERSITY · PI RANDOLPH, GWENDALYN J · 2016 to 2025
$4.3M
INTEGRATING CELL & LIPOPROTEIN TRAFFICKING WITH VASCULAR BIOLOGY IN HUMAN IBDDP1DK109668 · NIDDK · WASHINGTON UNIVERSITY · PI RANDOLPH, GWENDALYN J · 2015 to 2019
$3.8M
VEGF-C/VEGFR3 AND LYMPHATIC TRANSPORT OF CHOLESTEROL FROM ATHEROSCLEROTIC PLAQUER01HL118206 · NHLBI · WASHINGTON UNIVERSITY · PI RANDOLPH, GWENDALYN J · 2014 to 2017
$1.5M
CHEMOKINE RECEPTORS BASED NANOAGENTS IMAGING ATHEROSCLEROSISR01HL125655 · NHLBI · WASHINGTON UNIVERSITY · PI LIU, YONGJIAN · 2015 to 2018
$1.5M
NHLBI NIH HHS R01 HL118206NHLBI NIH HHS R01 HL125655NHLBI NIH HHS R35 HL145212NHLBI NIH HHS T32 HL007081NIAID NIH HHS R01 AI049653NIAID NIH HHS R37 AI049653NIBIB NIH HHS P41 EB025815NIDDK NIH HHS DP1 DK109668NIDDK NIH HHS P30 DK020579
6 · The paper itself

Abstract

objectivevMIP-II (viral macrophage inflammatory protein 2)/vCCL2 (viral chemotactic cytokine ligand 2) binds to multiple chemokine receptors, and vMIP-II-based positron emission tomography tracer (

conclusionsEndothelial injury status of plaques is marked by CXCR4 expression and this injury correlates with the tendency of such plaques to recruit monocytes. Furthermore, our findings suggest positron emission tomography tracers that mark CXCR4 can be used translationally to monitor the state of plaque injury and monocyte recruitment.

Indexed as

Molecular ImagingPositron-Emission TomographyAnimalsAorta, ThoracicAtherosclerosisBiomarkersCell LineChemokinesDisease Models, AnimalEndothelial CellsEndothelium, VascularInjections, IntravenousMaleMiceMice, Inbred C57BLMice, Knockout(64)Cu-DOTA-vMIP-IIBiomarkersChemokinesCXCR4 protein, mouseOrganometallic CompoundsRadiopharmaceuticalsReceptors, CXCR4atherosclerosisendothelial cellsfluorescencemonocytereceptor, chemokine

Identifiers

PMID33327748
PMCPMC8105279

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.