A Survey of Synthetic Routes and Antitumor Activities for Benzo[

Alain G Giuglio-Tonolo, Christophe Curti, Thierry Terme, Patrice Vanelle

Abstract readReview

In one paragraph

Review in Molecules (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it

0cells of the map it votes in

3citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

The Relevance and Insights on 1,4-Naphthoquinones as Antimicrobial and Antitumoral Molecules: A Systematic Review.Pharmaceuticals (Basel, Switzerland) · 2023
Review
Structures and electron affinity energies of polycyclic quinones.Heliyon · 2022
Article
Synthesis of novel antibacterial and antifungal quinoxaline derivatives.RSC advances · 2022
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Alain G Giuglio-TonoloEquipe Pharmaco-Chimie Radicalaire, Faculté de Pharmacie, Institut de Chimie Radicalaire, Aix Marseille Université, CNRS, UMR 7273, 27 Boulevard Jean Moulin, CEDEX 05, 13385 Marseille, France.

Christophe CurtiEquipe Pharmaco-Chimie Radicalaire, Faculté de Pharmacie, Institut de Chimie Radicalaire, Aix Marseille Université, CNRS, UMR 7273, 27 Boulevard Jean Moulin, CEDEX 05, 13385 Marseille, France.

Thierry TermeEquipe Pharmaco-Chimie Radicalaire, Faculté de Pharmacie, Institut de Chimie Radicalaire, Aix Marseille Université, CNRS, UMR 7273, 27 Boulevard Jean Moulin, CEDEX 05, 13385 Marseille, France.

Patrice VanelleEquipe Pharmaco-Chimie Radicalaire, Faculté de Pharmacie, Institut de Chimie Radicalaire, Aix Marseille Université, CNRS, UMR 7273, 27 Boulevard Jean Moulin, CEDEX 05, 13385 Marseille, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Anthracycline antibiotics play an important role in cancer chemotherapy. The need to improve their therapeutic index has stimulated an ongoing search for anthracycline analogs with enhanced properties. This review aims to summarize the common synthetic approaches to benzo[

Indexed as

Chemistry Techniques, SyntheticAnthraquinonesAntineoplastic AgentsCell Line, TumorGene Expression Regulation, NeoplasticHumansInhibitory Concentration 50NeoplasmsQuinoxalinesStructure-Activity RelationshipTopoisomerase InhibitorsTumor Suppressor Protein p53AnthraquinonesAntineoplastic AgentsQuinoxalinesTopoisomerase InhibitorsTumor Suppressor Protein p531,4-diazaanthraquinoneanthracene-9,10-dionebenzo[g]quinoxaline-5,10-dione

Identifiers

PMID33327601

DOI10.3390/molecules25245922

PMCPMC7765027

What OpenQuestion holds

Textmetadata

LicenceCC BY

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.