Evidence map›Paper›PMID 33327526›Full record

ArticlePolymers2020

An In-Silico Pipeline for Rapid Screening of DNA Aptamers against Mycotoxins: The Case-Study of Fumonisin B1, Aflatoxin B1 and Ochratoxin A.

Fulvio Ciriaco, Vincenzo De Leo, Lucia Catucci, Michelangelo Pascale, Antonio F Logrieco, Maria C DeRosa, Annalisa De Girolamo

Open access · goldAbstract read
In one paragraph

Article in Polymers, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Fulvio CiriacoDepartment of Chemistry, University of Bari, Via Orabona 4, 70126 Bari, Italy.ORCID 0000-0002-0695-6607
Vincenzo De LeoDepartment of Chemistry, University of Bari, Via Orabona 4, 70126 Bari, Italy.ORCID 0000-0001-7363-1899
Lucia CatucciDepartment of Chemistry, University of Bari, Via Orabona 4, 70126 Bari, Italy.ORCID 0000-0003-2206-9247
Michelangelo PascaleInstitute of Sciences of Food Production (ISPA), CNR-National Research Council of Italy, Via G. Amendola 122/O, 70126 Bari, Italy.ORCID 0000-0002-3898-1030
Antonio F LogriecoInstitute of Sciences of Food Production (ISPA), CNR-National Research Council of Italy, Via G. Amendola 122/O, 70126 Bari, Italy.
Maria C DeRosaDepartment of Chemistry, Carleton University, 1125 Colonel by Drive, Ottawa, ON K1S 5B6, Canada.ORCID 0000-0003-1868-6357
Annalisa De GirolamoInstitute of Sciences of Food Production (ISPA), CNR-National Research Council of Italy, Via G. Amendola 122/O, 70126 Bari, Italy.ORCID 0000-0002-3155-8002
Institute of Sciences of Food Production · ITUniversity of Bari Aldo Moro · ITCarleton University · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aptamers are single-stranded oligonucleotides selected by SELEX (Systematic Evolution of Ligands by EXponential Enrichment) able to discriminate target molecules with high affinity and specificity, even in the case of very closely related structures. Aptamers have been produced for several targets including small molecules like mycotoxins; however, the high affinity for their respective target molecules is a critical requirement. In the last decade, the screening through computational methods of aptamers for their affinity against specific targets has greatly increased and is becoming a commonly used procedure due to its convenience and low costs. This paper describes an in-silico approach for rapid screening of ten ssDNA aptamer sequences against fumonisin B1 (FB1,

Indexed as

aflatoxin B1binding affinityfumonisin B1in-silico approachmycotoxinsochratoxin AssDNA aptamers

Identifiers

PMID33327526
PMCPMC7764985
OpenAlexW3113117872

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.