ArticleInternational journal of molecular sciences2020
Maize microRNA166 Inactivation Confers Plant Development and Abiotic Stress Resistance.
Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it.
- What Do We Know about Barley miRNAs?International journal of molecular sciences · 2022Pooled it
- Article
- The miR164e-NAC32 module orchestrates maize plant height via post-translational regulation of DELLA protein stability.Plant communications · 2026Article
- Article
- Unlocking grass leaf development: foundations for tunable cereal design.The New phytologist · 2025Review
- Non-coding RNAs and their role in plants: prospective omics-tools for improving growth, development and stress tolerance in field crops.Molecular biology reports · 2025Review
- Comparative Long Non-Coding Transcriptome Analysis of Three Contrasting Barley Varieties in Response to Aluminum Stress.International journal of molecular sciences · 2024Article
- Review
- Comparative analysis of miRNA expression profiles in flowering and non-flowering tissue of Crocus sativus L.Protoplasma · 2024Article
- Knockdown of microRNA390 Enhances Maize Brace Root Growth.International journal of molecular sciences · 2024Article
- Participation of miR165a in the Phytochrome Signal Transduction in Maize (International journal of molecular sciences · 2024Article
- Article
- Mechanism of action of microRNA166 on nitric oxide in alfalfa (Medicago sativa L.) under drought stress.BMC genomics · 2024Article
- Article
- Characterization of the microRNA408-LACCASE5 module as a regulatory axis for photosynthetic efficiency inFrontiers in genetics · 2023Article
- Non-coding RNAs fine-tune the balance between plant growth and abiotic stress tolerance.Frontiers in plant science · 2022Review
- Genomics and transcriptomics to protect rice (Frontiers in plant science · 2022Review
- Recent developments in multi-omics and breeding strategies for abiotic stress tolerance in maize (Frontiers in plant science · 2022Review
- microRNA 166: an evolutionarily conserved stress biomarker in land plants targeting HD-ZIP family.Physiology and molecular biology of plants : an international journal of functional plant biology · 2021Review
- Molecular mechanism of modulating miR482b level in tomato with botrytis cinerea infection.BMC plant biology · 2021Article
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
MicroRNAs are important regulators in plant developmental processes and stress responses. In this study, we generated a series of maize STTM166 transgenic plants. Knock-down of miR166 resulted in various morphological changes, including rolled leaves, enhanced abiotic stress resistance, inferior yield-related traits, vascular pattern and epidermis structures, tassel architecture, as well as abscisic acid (ABA) level elevation and indole acetic acid (IAA) level reduction in maize. To profile miR166 regulated genes, we performed RNA-seq and qRT-PCR analysis. A total of 178 differentially expressed genes (DEGs) were identified, including 118 up-regulated and 60 down-regulated genes. These DEGs were strongly enriched in cell and intercellular components, cell membrane system components, oxidoreductase activity, single organism metabolic process, carbohydrate metabolic process, and oxidation reduction process. These results indicated that miR166 plays important roles in auxin and ABA interaction in monocots, yet the specific mechanism may differ from dicots. The enhanced abiotic stress resistance is partly caused via rolling leaves, high ABA content, modulated vascular structure, and the potential changes of cell membrane structure. The inferior yield-related traits and late flowering are partly controlled by the decreased IAA content, the interplay of miR166 with other miRNAs and AGOs. Taken together, the present study uncovered novel functions of miR166 in maize, and provide insights on applying short tandem target mimics (STTM) technology in plant breeding.
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