Evidence map›Paper›PMID 33327237›Full record

Trial reportMedicine2020

Effects of exercise training on bone mineral density and some health-related outcomes in HIV conditions: A randomized controlled trial.

Adedayo Tunde Ajidahun, Hellen Myezwa, Sam Chidi Ibeneme, Sebastian Magobotha, Gerhard Fortwengel, Maxwell Jingo, Brenda Milner, Sadiya Ravat, Ifeoma Okoye, Edward Schnaid and 1 more

Open access · goldAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.

  1. Pooled it
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 3 countries.

Adedayo Tunde AjidahunDepartment of Physiotherapy, University of the Witwatersrand, Johannesburg, South Africa.
Hellen MyezwaDepartment of Physiotherapy, University of the Witwatersrand, Johannesburg, South Africa.
Sam Chidi IbenemeDepartment of Physiotherapy, University of the Witwatersrand, Johannesburg, South Africa.
Sebastian MagobothaDepartment of Orthopaedic Surgery, University of the Witwatersrand, Johannesburg, South Africa.
Gerhard FortwengelHochschule Hannover - University of Applied Sciences and Arts, Hannover, Germany.
Maxwell JingoDepartment of Orthopaedic Surgery, University of the Witwatersrand, Johannesburg, South Africa.
Brenda MilnerDepartment of Orthopaedic Surgery, University of the Witwatersrand, Johannesburg, South Africa.
Sadiya RavatDepartment of Physiotherapy, University of the Witwatersrand, Johannesburg, South Africa.
Ifeoma OkoyeUniversity of Nigeria Teaching Hospital Enugu (UNTH), Ituku-Ozalla, Enugu State, Nigeria.
Edward SchnaidDepartment of Orthopaedic Surgery, University of the Witwatersrand, Johannesburg, South Africa.
Faith BischoffDepartment of Orthopaedic Surgery, University of the Witwatersrand, Johannesburg, South Africa.
University of the Witwatersrand · ZAHochschule Hannover · DEUniversity of Nigeria · NG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionHuman Immunodeficiency Virus (HIV) infection remains prevalent co-morbidity, and among fracture patients. Few studies have investigated the role of exercise interventions in preventing bone demineralization in people who have fractures and HIV. If exercise exposed, HIV-infected individuals may experience improved bone health outcomes (BMD), function, quality of life (QoL). The study will aim to assess the impact of home based exercises on bone mineral density, functional capacity, QoL, and some serological markers of health in HIV infection among Nigerians and South Africans. METHODS AND

designThe study is an assessor-blinded randomized controlled trial. Patients managed with internal and external fixation for femoral shaft fracture at the study sites will be recruited to participate in the study. The participants will be recruited 2 weeks post-discharge at the follow-up clinic with the orthopaedic surgeon. The study population will consist of all persons with femoral fracture and HIV-positive and negative (HIV-positive medically confirmed) aged 18 to 60 years attending the above-named health facilities. For the HIV-positive participants, a documented positive HIV result, as well as a history of being followed-up at the HIV treatment and care center. A developed home based exercise programme will be implemented in the experimental group while the control group continues with the usual rehabilitation programme. The primary outcome measures will be function, gait, bone mineral density, physical activity, and QoL. DISCUSSION: The proposed trial will compare the effect of a home-based physical exercise-training programme in the management of femoral fracture to the usual physiotherapy management programmes with specific outcomes of bone mineral density, function, and inflammatory markers.

trial registrationThe study was prospectively registered with the Pan African Clinical Trials Registry (Reference number - PACTR201910562118957) on October 21, 2019. (https://pactr.samrc.ac.za/TrialDisplay.aspx?TrialID=9425).

Indexed as

AdultBone DensityExerciseExercise TherapyFemaleFemoral FracturesFracture FixationFractures, BoneGaitHIV-1HIV InfectionsHumansMaleMiddle AgedNigeriaOutcome Assessment, Health Care

Identifiers

PMID33327237
PMCPMC7738028
OpenAlexW3111330538

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.