Evidence map›Paper›PMID 33327042›Full record

ArticleNMR in biomedicine2021

Water and lipid suppression techniques for advanced

Ivan Tkáč, Dinesh Deelchand, Wolfgang Dreher, Hoby Hetherington, Roland Kreis, Chathura Kumaragamage, Michal Považan, Daniel M Spielman, Bernhard Strasser, Robin A de Graaf

Abstract readConsensus Statement
In one paragraph

Article in NMR in biomedicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 1 synthesis or guideline pooled it.

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  11. Clinical application ofFrontiers in neuroscience · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ivan TkáčCenter for Magnetic Resonance Research, University of Minnesota, Minneapolis, Minnesota, USA.ORCID 0000-0001-5054-0150
Dinesh DeelchandCenter for Magnetic Resonance Research, University of Minnesota, Minneapolis, Minnesota, USA.ORCID 0000-0003-4266-4780
Wolfgang DreherDepartment of Chemistry, In vivo-MR Group, University Bremen, Bremen, Germany.ORCID 0000-0001-5132-6834
Hoby HetheringtonDepartment of Radiology Magnetic Resonance Research Center, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Roland KreisDepartments of Radiology and Biomedical Research, University Bern, Bern, Switzerland.ORCID 0000-0002-8618-6875
Chathura KumaragamageDepartment of Radiology and Biomedical Imaging, Magnetic Resonance Research Center, Yale University School of Medicine, New Haven, Connecticut, USA.ORCID 0000-0003-1251-7819
Michal PovažanRussell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.ORCID 0000-0002-5498-5162
Daniel M SpielmanDepartment of Radiology, Stanford University, Stanford, California, USA.
Bernhard StrasserDepartment of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, Massachusetts, USA.ORCID 0000-0001-9542-3855
Robin A de GraafDepartment of Radiology and Biomedical Imaging, Magnetic Resonance Research Center, Yale University School of Medicine, New Haven, Connecticut, USA.ORCID 0000-0002-6570-7010

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
TR&D 4: Algorithms for functional and anatomical brain analysisP41EB015909 · NIBIB · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI VAN ZIJL, PETER CM · 2012 to 2020
$13.1M
TRD4 - Ultrahigh Field Engineering and SafetyP41EB027061 · NIBIB · UNIVERSITY OF MINNESOTA · PI Gregory John Metzger · 2019 to 2026
$11.7M
Training and DisseminationP41EB015891 · NIBIB · STANFORD UNIVERSITY · PI GLOVER, GARY H · 2012 to 2019
$10.7M
NMR Imaging and SpectroscopyP41EB015894 · NIBIB · UNIVERSITY OF MINNESOTA · PI UGURBIL, KAMIL · 2012 to 2017
$8.4M
Institutional Center Cores for Advanced NeuroimagingP30NS076408 · NINDS · UNIVERSITY OF MINNESOTA · PI UGURBIL, KAMIL · 2012 to 2020
$4.2M
Robust 3D MR spectroscopic imaging through multi-coil magnetic field shapingR01EB014861 · NIBIB · YALE UNIVERSITY · PI DE GRAAF, ROBIN A · 2012 to 2020
$3.3M
Robust 1H MRSI of GABA, Glutamate, Glutamine, and Glutathione R01MH110683 · NIMH · STANFORD UNIVERSITY · PI SPIELMAN, DANIEL M · 2017 to 2020
$1.5M
Austrian Science Fund FWF J 4124NCATS NIH HHS UL1 TR001863NIBIB NIH HHS P41 EB015891NIBIB NIH HHS P41 EB015894NIBIB NIH HHS P41 EB015909NIBIB NIH HHS P41 EB027061NIBIB NIH HHS R01 EB014861NIMH NIH HHS R01 MH110683NINDS NIH HHS P30 NS076408
6 · The paper itself

Abstract

The neurochemical information provided by proton magnetic resonance spectroscopy (MRS) or MR spectroscopic imaging (MRSI) can be severely compromised if strong signals originating from brain water and extracranial lipids are not properly suppressed. The authors of this paper present an overview of advanced water/lipid-suppression techniques and describe their advantages and disadvantages. Moreover, they provide recommendations for choosing the most appropriate techniques for proper use. Methods of water signal handling are primarily focused on the VAPOR technique and on MRS without water suppression (metabolite cycling). The section on lipid-suppression methods in MRSI is divided into three parts. First, lipid-suppression techniques that can be implemented on most clinical MR scanners (volume preselection, outer-volume suppression, selective lipid suppression) are described. Second, lipid-suppression techniques utilizing the combination of k-space filtering, high spatial resolutions and lipid regularization are presented. Finally, three promising new lipid-suppression techniques, which require special hardware (a multi-channel transmit system for dynamic B

Indexed as

Magnetic Resonance ImagingProton Magnetic Resonance SpectroscopyBrainHumansLipidsMetabolomeRadio WavesSignal Processing, Computer-AssistedWaterLipidsWatercrusher coilsdynamic B1 shimmingECLIPSEhigh spatial resolutioninversion recoveryL-regularizationmetabolite cyclingVAPOR

Identifiers

PMID33327042
PMCPMC8569948

What OpenQuestion holds

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LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.