Evidence map›Paper›PMID 33326953›Full record

ReviewActa cytologica2021

Artificial Intelligence in Thyroid Fine Needle Aspiration Biopsies.

Brie Kezlarian, Oscar Lin

Registry-linked trialAbstract readReview
In one paragraph

Review in Acta cytologica, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06901908 (Role of Cytomorphometry and BRAFV600E Immunocytochemistry With a Cytologic Diagnosis "Suspicious for Papillary Thyroid Carcinoma"), which is not on this map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06901908 not yet recruitingnot on this mapstarted 2025, after this paper: background citation

Role of Cytomorphometry and BRAFV600E Immunocytochemistry With a Cytologic Diagnosis "Suspicious for Papillary Thyroid Carcinoma"

TypeobservationalSponsorAssiut UniversityRan2025 to 2027Enrolled45ConditionsSuspicious for Papillary Thyroid Carcinoma
3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
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  5. Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Thyroid Cytopathology Cancer Diagnosis from Smartphone Images Using Machine Learning.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2023
    Article
  13. Review
  14. Review
  15. Article
  16. Current status of machine learning in thyroid cytopathology.Journal of pathology informatics · 2023
    Review
  17. Review
  18. Article
  19. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Brie KezlarianDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Oscar LinDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York, USA, lino@mskcc.org.

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

backgroundFrom cell phones to aerospace, artificial intelligence (AI) has wide-reaching influence in the modern age. In this review, we discuss the application of AI solutions to an equally ubiquitous problem in cytopathology - thyroid fine needle aspiration biopsy (FNAB). Thyroid nodules are common in the general population, and FNAB is the sampling modality of choice. The resulting prevalence in the practicing pathologist's daily workload makes thyroid FNAB an appealing target for the application of AI solutions. SUMMARY: This review summarizes all available literature on the application of AI to thyroid cytopathology. We follow the evolution from morphometric analysis to convolutional neural networks. We explore the application of AI technology to different questions in thyroid cytopathology, including distinguishing papillary carcinoma from benign, distinguishing follicular adenoma from carcinoma and identifying non-invasive follicular thyroid neoplasm with papillary-like nuclear features by key words and phrases. Key Messages: The current literature shows promise towards the application of AI technology to thyroid fine needle aspiration biopsy. Much work is needed to define how this powerful technology will be of best use to the future of cytopathology practice.

Indexed as

Diagnosis, Computer-AssistedImage Interpretation, Computer-AssistedMachine LearningNeural Networks, ComputerBiopsy, Fine-NeedleDiagnosis, DifferentialHumansPredictive Value of TestsReproducibility of ResultsThyroid NeoplasmsArtificial intelligenceMachine learningThyroid fine needle aspiration biopsy

Identifiers

PMID33326953
PMCPMC8491503

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.