Evidence map›Paper›PMID 33326891›Full record

Trial reportJournal of affective disorders2021

Adding cognitive therapy to antidepressant medications decreases suicidal ideation.

Gabriela K Khazanov, Colin Xu, Steven D Hollon, Robert J DeRubeis, Michael E Thase

Registry-linked trialOpen access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of affective disorders, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00057577 (Prevention of Recurrence in Depression With Drugs and CT), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00057577 phase4completednot on this map

Prevention of Recurrence in Depression With Drugs and CT

TypeinterventionalSponsorVanderbilt UniversityRan2002 to 2014Enrolled452ConditionsDepressionArmsCognitive Therapy, Medications
3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 17 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Gabriela K KhazanovMental Illness Research, Education, and Clinical Center of the Veterans Integrated Service Network 4, Crescenz Veterans Affairs Medical Center. Electronic address: gabriela.khazanov@va.gov.
Colin XuDepartment of Psychology, University of Pennsylvania.
Steven D HollonDepartment of Psychology, Vanderbilt University.
Robert J DeRubeisDepartment of Psychology, University of Pennsylvania.
Michael E ThaseMental Illness Research, Education, and Clinical Center of the Veterans Integrated Service Network 4, Crescenz Veterans Affairs Medical Center.
University of Pennsylvania · USVanderbilt University · USVeterans Health Administration · US

Funding

PREVENTION OF RECURRENCE IN DEPRESSION WITH DRUGS AND CTR01MH060998 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI DERUBEIS, ROBERT J · 2002 to 2011
$6.5M
Prevention of Recurrence in Depression with Drugs and CTR01MH060713 · NIMH · VANDERBILT UNIVERSITY · PI HOLLON, STEVEN DENNIS · 2002 to 2011
$5.2M
Prevention of Recurrence in Depression with Drugs and CTK02MH001697 · NIMH · VANDERBILT UNIVERSITY · PI HOLLON, STEVEN DENNIS · 2000 to 2009
$1.2M
NIMH NIH HHS K02 MH001697NIMH NIH HHS R01 MH060713NIMH NIH HHS R01 MH060998
6 · The paper itself

Abstract

backgroundPsychotherapy for depression and antidepressant medications have both been associated with decreases in suicidal ideation. Studies have not examined whether adding psychotherapy to antidepressant medications further reduces suicidal ideation relative to medications alone in adults.

methodsParticipants (N = 452) were randomized to 7 months of treatment with antidepressant medications or combined treatment with both medications and cognitive therapy for depression. We examined change in the suicide items from the Beck Depression Inventory (BDI) and Hamilton Depression Rating Scale (HDRS) across treatment using Bayesian generalized linear mixed models for non-continuous outcomes.

resultsSuicidal ideation decreased across treatment. When measured with the BDI, participants receiving both cognitive therapy and antidepressant medications showed 17% greater reductions in suicidal ideation relative to those receiving medications alone; this effect remained significant when controlling for depression severity. While the same pattern was observed when suicidal ideation was measured with the HDRS, the effect was smaller (7%) and not statistically significant. When BDI and HDRS scores were combined, participants receiving both therapy and medications showed 9% greater reductions in suicidal ideation relative to those receiving medications alone; this effect was marginally significant when controlling for depression severity. LIMITATIONS: This is a secondary analysis of a randomized clinical trial designed to treat depression, in which suicidal ideation was assessed using single-item measures.

conclusionsAdding cognitive therapy to antidepressant medications may reduce suicidal ideation to a greater extent than medications alone. Pending replication, combination treatment may be preferred for individuals with suicidal ideation.

trial registrationclinicaltrials.gov Identifier: NCT00057577.

Indexed as

Cognitive Behavioral TherapyMajor Depressive DisorderAdultAntidepressive AgentsBayes TheoremHumansSuicidal IdeationAntidepressive Agentsantidepressant medicationscognitive therapydepressionSuicidal ideationtreatment outcome

Identifiers

PMID33326891
PMCPMC7855962
OpenAlexW3112307723

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.