Evidence map›Paper›PMID 33326797›Full record

ArticleDevelopmental biology2021

Taste buds are not derived from neural crest in mouse, chicken, and zebrafish.

Wenxin Yu, Zhonghou Wang, Brett Marshall, Yuta Yoshida, Renita Patel, Xiaogang Cui, Rebecca Ball, Linlin Yin, Fuminori Kawabata, Shoji Tabata and 4 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Developmental biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.5field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Review
  3. Developing and regenerating a sense of taste.Current topics in developmental biology · 2025
    Review
  4. Article
  5. The duct of von Ebner's glands is a source ofFrontiers in cell and developmental biology · 2024
    Article
  6. The avian taste system.Frontiers in physiology · 2023
    Review
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 3 countries.

Wenxin YuRegenerative Bioscience Center, The University of Georgia, Athens, GA, USA; Department of Animal and Dairy Science, College of Agricultural and Environmental Sciences, The University of Georgia, Athens, GA, USA.
Zhonghou WangRegenerative Bioscience Center, The University of Georgia, Athens, GA, USA; Department of Animal and Dairy Science, College of Agricultural and Environmental Sciences, The University of Georgia, Athens, GA, USA.
Brett MarshallRegenerative Bioscience Center, The University of Georgia, Athens, GA, USA; Department of Animal and Dairy Science, College of Agricultural and Environmental Sciences, The University of Georgia, Athens, GA, USA.
Yuta YoshidaRegenerative Bioscience Center, The University of Georgia, Athens, GA, USA; Department of Animal and Dairy Science, College of Agricultural and Environmental Sciences, The University of Georgia, Athens, GA, USA.
Renita PatelRegenerative Bioscience Center, The University of Georgia, Athens, GA, USA; Department of Animal and Dairy Science, College of Agricultural and Environmental Sciences, The University of Georgia, Athens, GA, USA.
Xiaogang CuiRegenerative Bioscience Center, The University of Georgia, Athens, GA, USA; Department of Animal and Dairy Science, College of Agricultural and Environmental Sciences, The University of Georgia, Athens, GA, USA.
Rebecca BallDepartment of Cellular Biology, Franklin College of Arts and Sciences, The University of Georgia, Athens, GA, USA.
Linlin YinDepartment of Molecular Physiology and Biophysics, School of Medicine, Vanderbilt University, Nashville, TN, USA.
Fuminori KawabataLaboratory of Functional Anatomy, Faculty of Agriculture, Kyushu University, Fukuoka, Japan.
Shoji TabataLaboratory of Functional Anatomy, Faculty of Agriculture, Kyushu University, Fukuoka, Japan.
Wenbiao ChenDepartment of Molecular Physiology and Biophysics, School of Medicine, Vanderbilt University, Nashville, TN, USA.
Robert N KelshDepartment of Biology and Biochemistry, University of Bath, Claverton Down, Bath, UK.
James D LauderdaleRegenerative Bioscience Center, The University of Georgia, Athens, GA, USA; Department of Cellular Biology, Franklin College of Arts and Sciences, The University of Georgia, Athens, GA, USA.
Hong-Xiang LiuRegenerative Bioscience Center, The University of Georgia, Athens, GA, USA; Department of Animal and Dairy Science, College of Agricultural and Environmental Sciences, The University of Georgia, Athens, GA, USA. Electronic address: lhx@uga.edu.
University of Georgia · USKyushu University · JPVanderbilt University · USUniversity of Bath · GB

Funding

Molecular Mechanisms of Postnatal Islet alpha-cell ProliferationR01DK117147 · NIDDK · VANDERBILT UNIVERSITY · PI CHEN, WENBIAO, POWERS, ALVIN C · 2019 to 2023
$3.1M
Taste organs: formation and regulationR01DC012308 · NIDCD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LIU, HONGXIANG · 2013 to 2017
$1.9M
A system for spatiotemporal gene inactivationR01DK088686 · NIDDK · VANDERBILT UNIVERSITY · PI CHEN, WENBIAO · 2010 to 2014
$1.7M
CRCNS: Quantum of Network Dysfunction in Epilepsy-Understanding the Inhibitory RestraintR01NS090645 · NINDS · UNIVERSITY OF GEORGIA · PI LAUDERDALE, JAMES D · 2014 to 2018
$1.6M
Taste Bud Cell Differentiation from SOX10-Expressing Progenitors in the Connective TissueR21DC018089 · NIDCD · UNIVERSITY OF GEORGIA · PI LIU, HONGXIANG · 2019 to 2020
$391k
Function and origin of circumvallate taste bud cells from SOX10 expressing von Ebners glandsR21DC018910 · NIDCD · UNIVERSITY OF GEORGIA · PI LIU, HONGXIANG · 2021 to 2022
$391k
NIDCD NIH HHS R01 DC012308NIDCD NIH HHS R21 DC018089NIDCD NIH HHS R21 DC018910NIDDK NIH HHS R01 DK088686NIDDK NIH HHS R01 DK117147NINDS NIH HHS R01 NS090645
6 · The paper itself

Abstract

Our lineage tracing studies using multiple Cre mouse lines showed a concurrent labeling of abundant taste bud cells and the underlying connective tissue with a neural crest (NC) origin, warranting a further examination on the issue of whether there is an NC derivation of taste bud cells. In this study, we mapped NC cell lineages in three different models, Sox10-iCreER

Indexed as

Cell LineageAnimalsChick EmbryoChickensMiceMice, TransgenicNeural CrestTaste BudsZebrafishChickenMouseNeural crestProgenitorsTaste budsZebrafish

Identifiers

PMID33326797
PMCPMC7855483
OpenAlexW3112036821

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.